Sleep duration, cognitive decline, and dementia risk in older women

Jiu Chiuan Chen, Mark A. Espeland, Robert L. Brunner, Laura C. Lovato, Robert B. Wallace, Xiaoyan Leng, Lawrence S. Phillips, Jennifer G. Robinson, Jane M. Kotchen, Karen Johnson, Joann E. Manson, Marcia L. Stefanick, Gloria E. Sarto, W. Jerry Mysiw

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65-80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995-2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant (P =.03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.

Original languageEnglish (US)
Pages (from-to)21-33
Number of pages13
JournalAlzheimer's and Dementia
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2016

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Dementia
Sleep
Cardiovascular Diseases
Independent Living
Women's Health
Proportional Hazards Models
Cognitive Dysfunction
Life Style
Prospective Studies
Depression

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Chen, J. C., Espeland, M. A., Brunner, R. L., Lovato, L. C., Wallace, R. B., Leng, X., ... Mysiw, W. J. (2016). Sleep duration, cognitive decline, and dementia risk in older women. Alzheimer's and Dementia, 12(1), 21-33. https://doi.org/10.1016/j.jalz.2015.03.004

Sleep duration, cognitive decline, and dementia risk in older women. / Chen, Jiu Chiuan; Espeland, Mark A.; Brunner, Robert L.; Lovato, Laura C.; Wallace, Robert B.; Leng, Xiaoyan; Phillips, Lawrence S.; Robinson, Jennifer G.; Kotchen, Jane M.; Johnson, Karen; Manson, Joann E.; Stefanick, Marcia L.; Sarto, Gloria E.; Mysiw, W. Jerry.

In: Alzheimer's and Dementia, Vol. 12, No. 1, 01.01.2016, p. 21-33.

Research output: Contribution to journalArticle

Chen, JC, Espeland, MA, Brunner, RL, Lovato, LC, Wallace, RB, Leng, X, Phillips, LS, Robinson, JG, Kotchen, JM, Johnson, K, Manson, JE, Stefanick, ML, Sarto, GE & Mysiw, WJ 2016, 'Sleep duration, cognitive decline, and dementia risk in older women', Alzheimer's and Dementia, vol. 12, no. 1, pp. 21-33. https://doi.org/10.1016/j.jalz.2015.03.004
Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X et al. Sleep duration, cognitive decline, and dementia risk in older women. Alzheimer's and Dementia. 2016 Jan 1;12(1):21-33. https://doi.org/10.1016/j.jalz.2015.03.004
Chen, Jiu Chiuan ; Espeland, Mark A. ; Brunner, Robert L. ; Lovato, Laura C. ; Wallace, Robert B. ; Leng, Xiaoyan ; Phillips, Lawrence S. ; Robinson, Jennifer G. ; Kotchen, Jane M. ; Johnson, Karen ; Manson, Joann E. ; Stefanick, Marcia L. ; Sarto, Gloria E. ; Mysiw, W. Jerry. / Sleep duration, cognitive decline, and dementia risk in older women. In: Alzheimer's and Dementia. 2016 ; Vol. 12, No. 1. pp. 21-33.
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