Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat

Vijayakumar Mavanji, Basavalingappa Meti, Subimal Datta

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The present study examined the effects of meta-chlorophenyl piperazine (mCPP) and mianserin on the sleep-wake cycle of the clomipramine-induced behaviorally screened depressed rats. Six-hour polygraphic recordings were made between 06:00 and 12:00 h, after a single injection of either saline or mianserin or mCPP into the lateral cerebral ventricle (i.c.v.) of both the depressed (n=12) and control rats (n=12). The injection of mCPP in the depressed rats caused a significant reduction in the total duration and number of rapid eye movement (REM) sleep episodes while it increased the REM sleep onset latency compared to the control saline injections. The injection of mianserin in the depressed rats also caused a significant reduction in the total duration and number of REM sleep episodes without changing the REM sleep latency. These results demonstrate for the first time that the central administration of mCPP and mianserin could act as an antidepressant in the clomipramine-induced rat model of depression.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalEuropean Journal of Pharmacology
Volume455
Issue number1
DOIs
StatePublished - Nov 22 2002

Fingerprint

Mianserin
REM Sleep
Sleep
Clomipramine
Injections
Cerebral Ventricles
Lateral Ventricles
Antidepressive Agents
piperazine
Depression

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat. / Mavanji, Vijayakumar; Meti, Basavalingappa; Datta, Subimal.

In: European Journal of Pharmacology, Vol. 455, No. 1, 22.11.2002, p. 35-41.

Research output: Contribution to journalArticle

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