Small-molecule microarrays

Development of novel linkers and an efficient detection method for bound proteins

Michio Kurosu, Williams A. Mowers

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Novel isocyanate and diazoketone linkers possessing polyoxypropylenediamine as a spacer for small-molecule microrray are developed. White light interferometry is introduced to detect bound proteins on the glass slides without using chemically modified proteins.

Original languageEnglish (US)
Pages (from-to)3392-3395
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number13
DOIs
StatePublished - Jul 1 2006

Fingerprint

Microarrays
Interferometry
Isocyanates
Molecules
Glass
Proteins
Light

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Small-molecule microarrays : Development of novel linkers and an efficient detection method for bound proteins. / Kurosu, Michio; Mowers, Williams A.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 13, 01.07.2006, p. 3392-3395.

Research output: Contribution to journalArticle

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