Solid phase synthesis of biologically important indoles

Shivaputra A. Patil, Renukadevi Patil, Duane Miller

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Combinatorial chemistry has become an important tool in the area of modern drug discovery and its success is partly dependent on further advances of solid phase organic synthesis (SPOS). Indoles are an important class of compounds with a broad spectrum of biological activities. Therefore, considerable attention is given for the development of effective methodology for the substituted indoles not only in solution phase but also on solid phase. In this review, indole forming classical reactions such as Fisher, Nenitzescu, Bartoli, Modified Madelung, Modified Bischler, and Wittig type reactions on solid support are summarized. In addition, metal mediated cyclizations such as palladium, and rhodium catalyzed cyclizations along with microwave-assisted solid phase synthesis of indoles have been discussed. Also, the most relevant biological properties of indoles have been reported.

Original languageEnglish (US)
Pages (from-to)2531-2565
Number of pages35
JournalCurrent Medicinal Chemistry
Volume16
Issue number20
DOIs
StatePublished - Sep 29 2009

Fingerprint

Indoles
Solid-Phase Synthesis Techniques
Cyclization
Synthetic Chemistry Techniques
Rhodium
Palladium
Drug Discovery
Microwaves
Bioactivity
Metals

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Solid phase synthesis of biologically important indoles. / Patil, Shivaputra A.; Patil, Renukadevi; Miller, Duane.

In: Current Medicinal Chemistry, Vol. 16, No. 20, 29.09.2009, p. 2531-2565.

Research output: Contribution to journalReview article

Patil, Shivaputra A. ; Patil, Renukadevi ; Miller, Duane. / Solid phase synthesis of biologically important indoles. In: Current Medicinal Chemistry. 2009 ; Vol. 16, No. 20. pp. 2531-2565.
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