Soluble TWEAK independently predicts atherosclerosis in renal transplant patients

Kultigin Turkmen, Halil Zeki Tonbul, Fatih Mehmet Erdur, Aysun Toker, Zeynep Biyik, Huseyin Ozbiner, Abduzhappar Gaipov, Elvin Enes Gul, Mehmet Kayrak, Yalcin Solak, Orhan Ozbek, Suleyman Turk, Adrian Covic

Research output: Contribution to journalArticle

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Abstract

Background: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intima-media thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in CKD patients. A novel markers, soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and neutrophil-to-lymphocyte ratio (NLR) were introduced as potential markers in inflammatory disorders including CKD. The role of Rtx in terms of atherogenesis is still unclear. We aimed to investigate the relationship between sTWEAK, NLR and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects. Methods. Cross-sectional analysis in which CIMT measurements, NLR and serum TWEAK levels were assessed in 70 Rtx patients (29 females; mean age, 40.6 ± 12.4 years) and 25 healthy subjects (13 females, mean age; 37.4±8.8 years). Results: sTWEAK levels were significantly decreased (p=0.01) and hs-CRP, NLR and CIMT levels of Rtx patients were significantly increased compared to healthy subjects (p<0.0001, p=0.001, p<0.0001, respectively). sTWEAK was also found to be decreased when eGFR was decreased (p=0.04 between all groups). CIMT was positively correlated with sTWEAK and NLR in Rtx patients (r=0.81, p<0.0001 and r=0.33, p=0.006, respectively). sTWEAK was also positively correlated with NLR (r=0.37, p=0.002). In the multivariate analysis only sTWEAK was found to be an independent variable of increased CIMT. Conclusion: sTWEAK might have a role in the pathogenesis of ongoing atherosclerosis in Rtx patients.

Original languageEnglish (US)
Article number144
JournalBMC Nephrology
Volume14
Issue number1
DOIs
StatePublished - Jul 16 2013

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Carotid Intima-Media Thickness
Atherosclerosis
Neutrophils
Transplants
Kidney
Lymphocytes
Chronic Renal Insufficiency
Healthy Volunteers
Cardiovascular Diseases
Multivariate Analysis
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Apoptosis
Mortality
Serum

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Turkmen, K., Tonbul, H. Z., Erdur, F. M., Toker, A., Biyik, Z., Ozbiner, H., ... Covic, A. (2013). Soluble TWEAK independently predicts atherosclerosis in renal transplant patients. BMC Nephrology, 14(1), [144]. https://doi.org/10.1186/1471-2369-14-144

Soluble TWEAK independently predicts atherosclerosis in renal transplant patients. / Turkmen, Kultigin; Tonbul, Halil Zeki; Erdur, Fatih Mehmet; Toker, Aysun; Biyik, Zeynep; Ozbiner, Huseyin; Gaipov, Abduzhappar; Gul, Elvin Enes; Kayrak, Mehmet; Solak, Yalcin; Ozbek, Orhan; Turk, Suleyman; Covic, Adrian.

In: BMC Nephrology, Vol. 14, No. 1, 144, 16.07.2013.

Research output: Contribution to journalArticle

Turkmen, K, Tonbul, HZ, Erdur, FM, Toker, A, Biyik, Z, Ozbiner, H, Gaipov, A, Gul, EE, Kayrak, M, Solak, Y, Ozbek, O, Turk, S & Covic, A 2013, 'Soluble TWEAK independently predicts atherosclerosis in renal transplant patients', BMC Nephrology, vol. 14, no. 1, 144. https://doi.org/10.1186/1471-2369-14-144
Turkmen K, Tonbul HZ, Erdur FM, Toker A, Biyik Z, Ozbiner H et al. Soluble TWEAK independently predicts atherosclerosis in renal transplant patients. BMC Nephrology. 2013 Jul 16;14(1). 144. https://doi.org/10.1186/1471-2369-14-144
Turkmen, Kultigin ; Tonbul, Halil Zeki ; Erdur, Fatih Mehmet ; Toker, Aysun ; Biyik, Zeynep ; Ozbiner, Huseyin ; Gaipov, Abduzhappar ; Gul, Elvin Enes ; Kayrak, Mehmet ; Solak, Yalcin ; Ozbek, Orhan ; Turk, Suleyman ; Covic, Adrian. / Soluble TWEAK independently predicts atherosclerosis in renal transplant patients. In: BMC Nephrology. 2013 ; Vol. 14, No. 1.
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abstract = "Background: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intima-media thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in CKD patients. A novel markers, soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and neutrophil-to-lymphocyte ratio (NLR) were introduced as potential markers in inflammatory disorders including CKD. The role of Rtx in terms of atherogenesis is still unclear. We aimed to investigate the relationship between sTWEAK, NLR and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects. Methods. Cross-sectional analysis in which CIMT measurements, NLR and serum TWEAK levels were assessed in 70 Rtx patients (29 females; mean age, 40.6 ± 12.4 years) and 25 healthy subjects (13 females, mean age; 37.4±8.8 years). Results: sTWEAK levels were significantly decreased (p=0.01) and hs-CRP, NLR and CIMT levels of Rtx patients were significantly increased compared to healthy subjects (p<0.0001, p=0.001, p<0.0001, respectively). sTWEAK was also found to be decreased when eGFR was decreased (p=0.04 between all groups). CIMT was positively correlated with sTWEAK and NLR in Rtx patients (r=0.81, p<0.0001 and r=0.33, p=0.006, respectively). sTWEAK was also positively correlated with NLR (r=0.37, p=0.002). In the multivariate analysis only sTWEAK was found to be an independent variable of increased CIMT. Conclusion: sTWEAK might have a role in the pathogenesis of ongoing atherosclerosis in Rtx patients.",
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AU - Turkmen, Kultigin

AU - Tonbul, Halil Zeki

AU - Erdur, Fatih Mehmet

AU - Toker, Aysun

AU - Biyik, Zeynep

AU - Ozbiner, Huseyin

AU - Gaipov, Abduzhappar

AU - Gul, Elvin Enes

AU - Kayrak, Mehmet

AU - Solak, Yalcin

AU - Ozbek, Orhan

AU - Turk, Suleyman

AU - Covic, Adrian

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