Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application

Himani Kalita, Prashanth Kumar Bhusetty Nagesh, Suraj Konar, Sangeeta Tantubay, Madhusudan Kr. Mahto, Mahitosh Mandal, Amita Pathak

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The present work reports the synthesis of biocompatible zirconium phosphate (ZP) nanoparticles as nanocarrier for drug delivery application. The ZP nanoparticles were synthesized via a simple sonochemical method in the presence of cetyltrimethylammonium bromide and their efficacy for the delivery of drugs has been tested through various in-vitro experiments. The particle size and BET surface area of the nanoparticles were found to be ∼ 48 nm and 206.51 m2/g respectively. The conventional MTT assay and cellular localization studies of the particles, performed on MDA-MB-231 cell lines, demonstrate their excellent biocompatibility and cellular internalization behavior. The loading of curcumin, an antitumor drug, onto the ZP nanoparticles shows the rapid drug uptake ability of the particles, while the drug release study, performed at two different pH values (at 7.4 and 5) depicts pH sensitive release-profile. The MTT assay and cellular localization studies revealed higher cellular inhibition and better bioavailability of the nanoformulated curcumin compared to free curcumin.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalMaterials Science and Engineering C
Volume60
DOIs
StatePublished - Mar 1 2016

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Drug delivery
Zirconium
Curcumin
delivery
phosphates
Phosphates
drugs
Nanoparticles
nanoparticles
Assays
Pharmaceutical Preparations
multiple docking adapters
bioavailability
Biocompatibility
Antineoplastic Agents
biocompatibility
cultured cells
Particle size
Cells
bromides

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application. / Kalita, Himani; Bhusetty Nagesh, Prashanth Kumar; Konar, Suraj; Tantubay, Sangeeta; Kr. Mahto, Madhusudan; Mandal, Mahitosh; Pathak, Amita.

In: Materials Science and Engineering C, Vol. 60, 01.03.2016, p. 84-91.

Research output: Contribution to journalArticle

Kalita, Himani ; Bhusetty Nagesh, Prashanth Kumar ; Konar, Suraj ; Tantubay, Sangeeta ; Kr. Mahto, Madhusudan ; Mandal, Mahitosh ; Pathak, Amita. / Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application. In: Materials Science and Engineering C. 2016 ; Vol. 60. pp. 84-91.
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