Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung

An argument for cyclical airway collapse and expansion

Scott Sinclair, Nayak L. Polissar, William A. Altemeier

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Ventilator-induced lung injury (VILI) is a recognized complication of mechanical ventilation. Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study, the application of positive end expiratory pressure (PEEP) reduces its severity. We have previously reported that VILI is spatially heterogeneous with the most severe injury in the dorsal-caudal lung. This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs.Methods: To test this hypothesis, rabbits were mechanically ventilated in the supine posture, and regional ventilation distribution was measured under four conditions: tidal volumes (VT) of 6 and 12 ml/kg with PEEP levels of 0 and 8 cm H2O.Results: We found that relative ventilation was sequentially redistributed towards dorsal-caudal lung with increasing tidal volume. This sequential ventilation redistribution was abolished with the addition of PEEP.Conclusions: These results suggest that cyclical airway collapse and recruitment is regionally heterogeneous and spatially correlated with areas most susceptible to VILI.

Original languageEnglish (US)
Article number25
JournalBMC Pulmonary Medicine
Volume10
DOIs
StatePublished - May 5 2010

Fingerprint

Positive-Pressure Respiration
Ventilator-Induced Lung Injury
Artificial Respiration
Ventilation
Lung
Tidal Volume
Lung Injury
Wounds and Injuries
Posture
Rabbits

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung : An argument for cyclical airway collapse and expansion. / Sinclair, Scott; Polissar, Nayak L.; Altemeier, William A.

In: BMC Pulmonary Medicine, Vol. 10, 25, 05.05.2010.

Research output: Contribution to journalArticle

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