Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat

Il Hwan Kim, Soon Kwon Park, Woong Sun, Yunhee Kang, Hyun Taek Kim, Hyun Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalMolecular Brain Research
Volume124
Issue number1
DOIs
StatePublished - Apr 29 2004
Externally publishedYes

Fingerprint

Inositol 1,4,5-trisphosphate 3-kinase
Hippocampus
Dendritic Spines
Calcium Signaling
Messenger RNA
Neuronal Plasticity
Inositol 1,4,5-Trisphosphate
Long-Term Memory
Water
Enzymes
In Situ Hybridization
Proteins
Homeostasis
Maintenance
Spatial Learning
Calcium
Neurons

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat. / Kim, Il Hwan; Park, Soon Kwon; Sun, Woong; Kang, Yunhee; Kim, Hyun Taek; Kim, Hyun.

In: Molecular Brain Research, Vol. 124, No. 1, 29.04.2004, p. 12-19.

Research output: Contribution to journalArticle

Kim, Il Hwan ; Park, Soon Kwon ; Sun, Woong ; Kang, Yunhee ; Kim, Hyun Taek ; Kim, Hyun. / Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat. In: Molecular Brain Research. 2004 ; Vol. 124, No. 1. pp. 12-19.
@article{57e7a0d810b84fb694130cf99868ad8e,
title = "Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat",
abstract = "Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.",
author = "Kim, {Il Hwan} and Park, {Soon Kwon} and Woong Sun and Yunhee Kang and Kim, {Hyun Taek} and Hyun Kim",
year = "2004",
month = "4",
day = "29",
doi = "10.1016/j.molbrainres.2003.12.016",
language = "English (US)",
volume = "124",
pages = "12--19",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat

AU - Kim, Il Hwan

AU - Park, Soon Kwon

AU - Sun, Woong

AU - Kang, Yunhee

AU - Kim, Hyun Taek

AU - Kim, Hyun

PY - 2004/4/29

Y1 - 2004/4/29

N2 - Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

AB - Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

UR - http://www.scopus.com/inward/record.url?scp=1942485771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942485771&partnerID=8YFLogxK

U2 - 10.1016/j.molbrainres.2003.12.016

DO - 10.1016/j.molbrainres.2003.12.016

M3 - Article

VL - 124

SP - 12

EP - 19

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -