Spatial organization, predictability, and determinism in ventricular fibrillation

P. V. Bayly, B. H. KenKnight, J. M. Rogers, Eric Johnson, R. E. Ideker, W. M. Smith

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The degree of spatial organization of ventricular fibrillation (VF) is a fundamental dynamical property of the arrhythmia and may determine the success of proposed therapeutic approaches. Spatial organization is closely related to the dimension of VF, and hence to its predictability and controllability. We have explored several techniques to quantify spatial organization during VF, to predict patterns of activity, and to see how spatial organization and predictability change as the arrhythmia progresses. Epicardial electrograms recorded from pig hearts using rectangular arrays of unipolar extracellular electrodes (1 mm spacing) were analyzed. The correlation length of VF, the number of Karhunen-Loève modes required to approximate data during VF, the number, size and recurrence of wavefronts, and the mean square error of epicardial potential fields predicted 0.256 seconds into the future were all estimated. The ability of regularly-timed pacing stimuli to capture areas of fibrillating myocardium during VF was confirmed by a significant increase in local spatial organization. Results indicate that VF is neither "low-dimensional chaos" (dimension <5) nor "random" behavior (dimension=∞), but is a high-dimensional response with a degree of spatial coherence that changes as the arrhythmia progresses.

Original languageEnglish (US)
Pages (from-to)103-115
Number of pages13
JournalChaos
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1998

Fingerprint

fibrillation
Ventricular Fibrillation
Determinism
Predictability
arrhythmia
Arrhythmia
Wavefronts
Controllability
Chaos theory
Mean square error
myocardium
swine
Myocardium
Potential Field
controllability
potential fields
Correlation Length
Wave Front
Recurrence
stimuli

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Physics and Astronomy(all)
  • Applied Mathematics

Cite this

Bayly, P. V., KenKnight, B. H., Rogers, J. M., Johnson, E., Ideker, R. E., & Smith, W. M. (1998). Spatial organization, predictability, and determinism in ventricular fibrillation. Chaos, 8(1), 103-115. https://doi.org/10.1063/1.166291

Spatial organization, predictability, and determinism in ventricular fibrillation. / Bayly, P. V.; KenKnight, B. H.; Rogers, J. M.; Johnson, Eric; Ideker, R. E.; Smith, W. M.

In: Chaos, Vol. 8, No. 1, 01.01.1998, p. 103-115.

Research output: Contribution to journalArticle

Bayly, PV, KenKnight, BH, Rogers, JM, Johnson, E, Ideker, RE & Smith, WM 1998, 'Spatial organization, predictability, and determinism in ventricular fibrillation', Chaos, vol. 8, no. 1, pp. 103-115. https://doi.org/10.1063/1.166291
Bayly, P. V. ; KenKnight, B. H. ; Rogers, J. M. ; Johnson, Eric ; Ideker, R. E. ; Smith, W. M. / Spatial organization, predictability, and determinism in ventricular fibrillation. In: Chaos. 1998 ; Vol. 8, No. 1. pp. 103-115.
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