Spatiotemporal patterns of brain activation during an action naming task using magnetoencephalography

Joshua I. Breier, Andrew Papanicolaou

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Eight right-handed subjects were asked to silently generate a verb to a visual stimulus while the magnetic flux normal to the scalp surface was recorded with a whole-head neuromagnetometer. The spatiotemporal patterns of activation in lateral occipital, inferior parietal, superior temporal, basal temporal, and inferior frontal cortices were estimated using minimum estimation, a distributed source analysis methodology. Although there was significant variability among subjects, averaged data indicated that latencies of peak activation in these regions of interest progressed from posterior to anterior. Peak latencies were earliest in lateral occipital cortex and latest in pars opercularis and pars triangularis in the inferior frontal gyrus. Lateralization of activation was strongest in pars opercularis, which is part of classical Broca's area, with activation being stronger in this area within the left hemisphere in every subject. Results provide support for the use of magnetoencephalography in conjunction with MNE analysis for the purpose of lateralizing and localizing language-specific activation in frontal areas as well as the study of the spatiotemporal parameters of brain activation associated with cognitive function.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalJournal of Clinical Neurophysiology
Volume25
Issue number1
DOIs
StatePublished - Feb 1 2008

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Magnetoencephalography
Brain
Occipital Lobe
Frontal Lobe
Prefrontal Cortex
Scalp
Cognition
Language
Head
Broca Area

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology
  • Neuroscience(all)

Cite this

Spatiotemporal patterns of brain activation during an action naming task using magnetoencephalography. / Breier, Joshua I.; Papanicolaou, Andrew.

In: Journal of Clinical Neurophysiology, Vol. 25, No. 1, 01.02.2008, p. 7-12.

Research output: Contribution to journalArticle

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