Spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma

Benjamin A. King, Carlos Parra, Yimei Li, Kathleen J. Helton, Ibrahim Qaddoumi, Matthew Wilson, Robert J. Ogg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma. Methods: Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from images in three orthogonal planes. The centroid of the mapped area was calculated to approximate tumor origin, and the location and cumulative tumor burden were analyzed in relation to mutation type (germline vs. somatic), tumor area, and patient age at diagnosis. Location of small tumors undetected by MRI was approximated with fundoscopic images. Results: Mapping was successful for 129 tumors in 91 eyes from 67 patients (39 bilateral, 43 germline mutation). Cumulative tumor burden was highest within the macula and posterior pole and was asymmetrically higher within the inferonasal periphery. Tumor incidence was lowest in the superotemporal periphery. Tumor location varied with age at diagnosis in a complex pattern. Tumor location was concentrated in the macula and superonasal periphery in patients <5.6 months, in the inferotemporal quadrant of the posterior pole in patients 5.6-8.8 months, in the inferonasal quadrant in patients 8.8-13.2 months, and in the nasal and superotemporal periphery in patients >13.2 months. The distribution of MRI-invisible tumors was consistent with the asymmetry of mapped tumors. Conclusions: MRI-based mapping revealed a previously unrecognized pattern of retinoblastoma localization that evolves with age at diagnosis. The structured spatiotemporal distribution of tumors may provide valuable clues about cellular or molecular events associated with tumorigenesis in the developing retina.

Original languageEnglish (US)
Article numbere0132932
JournalPloS one
Volume10
Issue number7
DOIs
StatePublished - Jul 31 2015

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Retinoblastoma
Tumors
neoplasms
Neoplasms
Magnetic resonance imaging
Germ-Line Mutation
Tumor Burden
Retina
retina
germ cells
Acoustic Neuroma
mutation
Triangulation
Carcinogenesis
carcinogenesis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

King, B. A., Parra, C., Li, Y., Helton, K. J., Qaddoumi, I., Wilson, M., & Ogg, R. J. (2015). Spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma. PloS one, 10(7), [e0132932]. https://doi.org/10.1371/journal.pone.0132932

Spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma. / King, Benjamin A.; Parra, Carlos; Li, Yimei; Helton, Kathleen J.; Qaddoumi, Ibrahim; Wilson, Matthew; Ogg, Robert J.

In: PloS one, Vol. 10, No. 7, e0132932, 31.07.2015.

Research output: Contribution to journalArticle

King, Benjamin A. ; Parra, Carlos ; Li, Yimei ; Helton, Kathleen J. ; Qaddoumi, Ibrahim ; Wilson, Matthew ; Ogg, Robert J. / Spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma. In: PloS one. 2015 ; Vol. 10, No. 7.
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