Specific and nonspecific NK cell activation during virus infection

Ayotunde Dokun, Sungjin Kim, Hamish R.C. Smith, Hyun Seok P. Kang, Dortha T. Chu, Wayne M. Yokoyama

Research output: Contribution to journalArticle

322 Citations (Scopus)

Abstract

The natural killer (NK) cell activation receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV). We show here that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection. During a later phase of infection, however, Ly49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration. With vaccinia virus infection, neither the early nor late phase of NK cell proliferation was selective for Ly49H+ NK cells. These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo.

Original languageEnglish (US)
Pages (from-to)951-956
Number of pages6
JournalNature Immunology
Volume2
Issue number10
DOIs
StatePublished - Oct 29 2001
Externally publishedYes

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Virus Diseases
Natural Killer Cells
Muromegalovirus
Cytomegalovirus Infections
Cell Proliferation
Natural Killer Cell Receptors
Vaccinia virus
Interferons
Infection

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Dokun, A., Kim, S., Smith, H. R. C., Kang, H. S. P., Chu, D. T., & Yokoyama, W. M. (2001). Specific and nonspecific NK cell activation during virus infection. Nature Immunology, 2(10), 951-956. https://doi.org/10.1038/ni714

Specific and nonspecific NK cell activation during virus infection. / Dokun, Ayotunde; Kim, Sungjin; Smith, Hamish R.C.; Kang, Hyun Seok P.; Chu, Dortha T.; Yokoyama, Wayne M.

In: Nature Immunology, Vol. 2, No. 10, 29.10.2001, p. 951-956.

Research output: Contribution to journalArticle

Dokun, A, Kim, S, Smith, HRC, Kang, HSP, Chu, DT & Yokoyama, WM 2001, 'Specific and nonspecific NK cell activation during virus infection', Nature Immunology, vol. 2, no. 10, pp. 951-956. https://doi.org/10.1038/ni714
Dokun A, Kim S, Smith HRC, Kang HSP, Chu DT, Yokoyama WM. Specific and nonspecific NK cell activation during virus infection. Nature Immunology. 2001 Oct 29;2(10):951-956. https://doi.org/10.1038/ni714
Dokun, Ayotunde ; Kim, Sungjin ; Smith, Hamish R.C. ; Kang, Hyun Seok P. ; Chu, Dortha T. ; Yokoyama, Wayne M. / Specific and nonspecific NK cell activation during virus infection. In: Nature Immunology. 2001 ; Vol. 2, No. 10. pp. 951-956.
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