Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome

John Stanley, R. R. Hanson, G. A. Hicklin, A. J. Glazier, A. Ervanian, M. Jadali, B. Turner, L. J. Greenfield

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Abstract

The diagnosis of fat embolism syndrome (FES) is relatively difficult because simple, quantitative criteria have been lacking. The results of a recent study, however, suggest that the diagnosis of FES can be made if more than 5 per cent of the cells in fluid obtained by bronchoalveolar lavage are lipid-laden. Our study was designed to assess the specificity of this lipid staining test of bronchoalveolar cells for diagnosing FES in a series of patients coming to the pulmonology clinic. Thirty-four consecutive patients with suspected pulmonary diseases, but not FES, underwent routine bronchoscopy. Bronchoalveolar fluid was applied to slides, fixed with formalin, and stained with oil red 0. Three hundred consecutive cells of each specimen were observed for red-staining droplets. More than 5 per cent of bronchoalveolar lavage cells stained for lipids in 25 of the 34 subjects. The calculated specificity, assuming a negative finding is defined as ≤ 5 per cent lipid-laden cells in the sample, was 26.5 per cent. We conclude that staining of bronchoalveolar lavage cells for lipids is not a specific test for FES.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalAmerican Surgeon
Volume60
Issue number7
StatePublished - Jan 1 1994
Externally publishedYes

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Fat Embolism
Bronchoalveolar Lavage
Lipids
Staining and Labeling
Pulmonary Medicine
Bronchoalveolar Lavage Fluid
Bronchoscopy
Formaldehyde
Lung Diseases
Oils

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Stanley, J., Hanson, R. R., Hicklin, G. A., Glazier, A. J., Ervanian, A., Jadali, M., ... Greenfield, L. J. (1994). Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome. American Surgeon, 60(7), 537-541.

Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome. / Stanley, John; Hanson, R. R.; Hicklin, G. A.; Glazier, A. J.; Ervanian, A.; Jadali, M.; Turner, B.; Greenfield, L. J.

In: American Surgeon, Vol. 60, No. 7, 01.01.1994, p. 537-541.

Research output: Contribution to journalArticle

Stanley, J, Hanson, RR, Hicklin, GA, Glazier, AJ, Ervanian, A, Jadali, M, Turner, B & Greenfield, LJ 1994, 'Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome', American Surgeon, vol. 60, no. 7, pp. 537-541.
Stanley J, Hanson RR, Hicklin GA, Glazier AJ, Ervanian A, Jadali M et al. Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome. American Surgeon. 1994 Jan 1;60(7):537-541.
Stanley, John ; Hanson, R. R. ; Hicklin, G. A. ; Glazier, A. J. ; Ervanian, A. ; Jadali, M. ; Turner, B. ; Greenfield, L. J. / Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome. In: American Surgeon. 1994 ; Vol. 60, No. 7. pp. 537-541.
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