SPECT abnormalities in generalized dystonia

Mark Ledoux, S. Lane Rutledge, James M. Mountz, Jaykrishna T. Darji

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A patient with severe, generalized dystonia and 6 age range-matched controls were studied with the regional cerebral blood flow tracer technetium-99m hexamethylpropyleneamine oxime by single-photon emission computed tomography to test the hypothesis that cerebellar function is abnormal in dystonia. Analysis was performed by drawing regions of interest around the caudate head nuclei, hemithalami, deep cerebellar nuclei, and cerebellar hemicortices. The counts in each region of interest were normalized to whole brain cerebral blood flow in an identical manner for each subject. The dystonic patient had a difference in regional cerebral blood flow between the right and left deep cerebellar nuclei, increased regional cerebral blood flow in subcortical motor structures, and an abnormal relationship between right cerebellar cortical and right deep cerebellar nuclear regional cerebral blood flow. The findings in this patient provide evidence that the cerebellum may play a role in the pathophysiology of motor signs in some patients with dystonia.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalPediatric Neurology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1995

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Cerebrovascular Circulation
Dystonia
Single-Photon Emission-Computed Tomography
Regional Blood Flow
Cerebellar Nuclei
Caudate Nucleus
Technetium
Cerebellum
Head
Brain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

SPECT abnormalities in generalized dystonia. / Ledoux, Mark; Lane Rutledge, S.; Mountz, James M.; Darji, Jaykrishna T.

In: Pediatric Neurology, Vol. 13, No. 1, 01.01.1995, p. 5-10.

Research output: Contribution to journalArticle

Ledoux, M, Lane Rutledge, S, Mountz, JM & Darji, JT 1995, 'SPECT abnormalities in generalized dystonia', Pediatric Neurology, vol. 13, no. 1, pp. 5-10. https://doi.org/10.1016/0887-8994(95)00109-S
Ledoux, Mark ; Lane Rutledge, S. ; Mountz, James M. ; Darji, Jaykrishna T. / SPECT abnormalities in generalized dystonia. In: Pediatric Neurology. 1995 ; Vol. 13, No. 1. pp. 5-10.
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