SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model

Enrique Izaguirre, Mingshan Sun, Daryl C. Drummond, Dmitri B. Kirpotin, Tobias Funk, Steve Thompson, James Carver, Mark E. Hayes, Michael Wendland, Mark Knudsen, Bruce H. Hasegawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Liposomal drugs offer the promise of an improved therapeutic index due to improvements in the specific delivery of anti-cancer agents to tumors. The presented work concentrates on imaging the tumor uptake of 111In- labeled liposomes noninvasively as a specific tumor drug delivery carrier in a murine cancer model. The tumor uptake of liposomes has been imaged using a microSPECT/microCT small animal dedicated scanner prototype constructed at our laboratory. The imaging system consists of a high resolution SPECT (700 μm) and high resolution CT (70 μm). The SPECT subsystem consists in specially designed CZT gamma cameras shielded for energies up to 250 keV. The mice were injected with liposomes and scanned at the time of maximum tumor uptake (24 h). The total activity of the mouse samples was of the order of 250 uCi, and with tumor sizes of 1000-1500 mm3. The imaging geometries in the CT and SPECT acquisitions were selected to obtain high magnification and high efficiency to image the tumor located within the torso. The SPECT and CT projections were taken sequentially. The acquired images show that necrotic tumors can de imaged with high resolution to observe liposome inhomogeneous uptake.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages1965-1968
Number of pages4
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

Fingerprint

Liposomes
delivery
drugs
tumors
cancer
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
mice
high resolution
Single-Photon Emission-Computed Tomography
torso
Single Photon Emission Computed Tomography Computed Tomography
Torso
X-Ray Microtomography
magnification
Drug Carriers
Gamma Cameras
scanners
animals

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Izaguirre, E., Sun, M., Drummond, D. C., Kirpotin, D. B., Funk, T., Thompson, S., ... Hasegawa, B. H. (2005). SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference (pp. 1965-1968). [1596717] (IEEE Nuclear Science Symposium Conference Record; Vol. 4). https://doi.org/10.1109/NSSMIC.2005.1596717

SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model. / Izaguirre, Enrique; Sun, Mingshan; Drummond, Daryl C.; Kirpotin, Dmitri B.; Funk, Tobias; Thompson, Steve; Carver, James; Hayes, Mark E.; Wendland, Michael; Knudsen, Mark; Hasegawa, Bruce H.

2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. p. 1965-1968 1596717 (IEEE Nuclear Science Symposium Conference Record; Vol. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Izaguirre, E, Sun, M, Drummond, DC, Kirpotin, DB, Funk, T, Thompson, S, Carver, J, Hayes, ME, Wendland, M, Knudsen, M & Hasegawa, BH 2005, SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model. in 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference., 1596717, IEEE Nuclear Science Symposium Conference Record, vol. 4, pp. 1965-1968, Nuclear Science Symposium Conference Record, 2005 IEEE, Puerto Rico, 10/23/05. https://doi.org/10.1109/NSSMIC.2005.1596717
Izaguirre E, Sun M, Drummond DC, Kirpotin DB, Funk T, Thompson S et al. SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. p. 1965-1968. 1596717. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2005.1596717
Izaguirre, Enrique ; Sun, Mingshan ; Drummond, Daryl C. ; Kirpotin, Dmitri B. ; Funk, Tobias ; Thompson, Steve ; Carver, James ; Hayes, Mark E. ; Wendland, Michael ; Knudsen, Mark ; Hasegawa, Bruce H. / SPECT- CT study of directed drug delivery using 111In-labeled liposomes in a murine mammary carcinoma model. 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference. 2005. pp. 1965-1968 (IEEE Nuclear Science Symposium Conference Record).
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