Spectrin expression during mammalian brain ontogeny

Ian S. Zagon, Beat M. Riederer, Steven Goodman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

At least 2 distinct spectrin subtypes, brain spectrin(240/235) and brain spectrin (240/235E), are contained in the mammalian brain. Evidence that these subtypes are differentially expressed during mouse brain development is reviewed. Brain spectrin(240/235) is detected in fetal brain tissues, and increases 2-fold to adult levels. This subtype is enriched in the cortical cytoplasm of germinative neural cells, and is also associated with fibers resembling axons in the fetus. Brain spectrin(240/235E), a brain subtype specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in the fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is found in the cell body and dendrites of differentiating neurons and glial cells, but is not expressed in mitotic cells. This subtype is especially prominent in granule cells of the cerebellum and dentate gyrus. The potential function of these spectrin subtypes during neuro-ontogeny is discussed.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalBrain Research Bulletin
Volume18
Issue number6
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Spectrin
Brain
Fetus
Dentate Gyrus
Dendrites
Neuroglia
Cerebellum
Axons
Limit of Detection
Cytoplasm
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Spectrin expression during mammalian brain ontogeny. / Zagon, Ian S.; Riederer, Beat M.; Goodman, Steven.

In: Brain Research Bulletin, Vol. 18, No. 6, 01.01.1987, p. 799-807.

Research output: Contribution to journalArticle

Zagon, Ian S. ; Riederer, Beat M. ; Goodman, Steven. / Spectrin expression during mammalian brain ontogeny. In: Brain Research Bulletin. 1987 ; Vol. 18, No. 6. pp. 799-807.
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