Splenic artery embolization with Ankaferd blood stopper in a sheep model

Osman Koç, Kadir Acar, Orhan Özbek, İbrahim Güler, Kadir Sarıtaş, Tuba Bera Erdem, Yalçın Solak, Hatice Toy, Ahmet Küçükapan, Seda Özbek, Abduzhappar Gaipov, İbrahim C. Haznedaroğlu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%-95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the shortterm. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalDiagnostic and Interventional Radiology
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2016

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Splenic Artery
Sheep
Hemostatics
Abdomen
Angiography
Blood Coagulation Factors
Deceleration
Thiopental
Fluoroscopy
Contrast Media
Thrombosis
Spleen
Catheters
Safety
ankaferd blood stopper
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Koç, O., Acar, K., Özbek, O., Güler, İ., Sarıtaş, K., Erdem, T. B., ... Haznedaroğlu, İ. C. (2016). Splenic artery embolization with Ankaferd blood stopper in a sheep model. Diagnostic and Interventional Radiology, 22(4), 354-357. https://doi.org/10.5152/dir.2015.15382

Splenic artery embolization with Ankaferd blood stopper in a sheep model. / Koç, Osman; Acar, Kadir; Özbek, Orhan; Güler, İbrahim; Sarıtaş, Kadir; Erdem, Tuba Bera; Solak, Yalçın; Toy, Hatice; Küçükapan, Ahmet; Özbek, Seda; Gaipov, Abduzhappar; Haznedaroğlu, İbrahim C.

In: Diagnostic and Interventional Radiology, Vol. 22, No. 4, 01.07.2016, p. 354-357.

Research output: Contribution to journalArticle

Koç, O, Acar, K, Özbek, O, Güler, İ, Sarıtaş, K, Erdem, TB, Solak, Y, Toy, H, Küçükapan, A, Özbek, S, Gaipov, A & Haznedaroğlu, İC 2016, 'Splenic artery embolization with Ankaferd blood stopper in a sheep model', Diagnostic and Interventional Radiology, vol. 22, no. 4, pp. 354-357. https://doi.org/10.5152/dir.2015.15382
Koç, Osman ; Acar, Kadir ; Özbek, Orhan ; Güler, İbrahim ; Sarıtaş, Kadir ; Erdem, Tuba Bera ; Solak, Yalçın ; Toy, Hatice ; Küçükapan, Ahmet ; Özbek, Seda ; Gaipov, Abduzhappar ; Haznedaroğlu, İbrahim C. / Splenic artery embolization with Ankaferd blood stopper in a sheep model. In: Diagnostic and Interventional Radiology. 2016 ; Vol. 22, No. 4. pp. 354-357.
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