Standardized uptake value and influx. Constant

relationships and variabilities, with: Model interpretation and clinical implications

Joseph A. Thie, Karl Hubner, Gary T. Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Useful characterizing parameters have been derived from historical positron emission tomography (PET) standardized uptake values (SUV) and influx constants K. Meta-analysis was performed on 30 multipatient PET oncological studies providing same patient SUVs and K's. Averaged results for fluorine-18 fluorodeoxyglucose (FDG) and L -methionine respectively were: SUV vs. K correlation coefficients = 0.89 and 0.80; SUV/K ratios =192 and 63 minutes as average tracer clearance times T in these populations. For cancers, coefficients of variation (CV) for K's were 0.61 and 0.46, notably larger than the CVs (0.50 and 0.40) for SUVs. A Monte Carlo simulation model, matching these results, represents 1/T as (an effective tracer clearance rate) × (its initial distribution volume). We conclude that T is a characteristic tracer clearance time that is independent of cancer type. A measurement model is introduced that might help improve protocols. The higher CVs of K's vs. SUVs is worth noting clinically when seeking an effective diagnostic marker. Also, SUV conversions to K can provide some quality assurance in K measurements.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalClinical Positron Imaging (Netherlands)
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1999

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Positron-Emission Tomography
Fluorodeoxyglucose F18
Methionine
Meta-Analysis
Neoplasms
Population

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Standardized uptake value and influx. Constant : relationships and variabilities, with: Model interpretation and clinical implications. / Thie, Joseph A.; Hubner, Karl; Smith, Gary T.

In: Clinical Positron Imaging (Netherlands), Vol. 2, No. 2, 01.01.1999, p. 99-104.

Research output: Contribution to journalArticle

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