Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides

Barbara Menzies, Aimee Kenoyer

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.

Original languageEnglish (US)
Pages (from-to)5241-5244
Number of pages4
JournalInfection and Immunity
Volume73
Issue number8
DOIs
StatePublished - Aug 1 2005

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Keratinocytes
Staphylococcus aureus
Peptides
Up-Regulation
Infection
Epithelium
Hot Temperature
Skin

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides. / Menzies, Barbara; Kenoyer, Aimee.

In: Infection and Immunity, Vol. 73, No. 8, 01.08.2005, p. 5241-5244.

Research output: Contribution to journalArticle

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