STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

Lawrence Pfeffer, Jerald E. Mullersman, Susan R. Pfeffer, Aruna Murti, Wei Shi, Chuan Yang

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine. STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3- kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation. Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.

Original languageEnglish (US)
Pages (from-to)1418-1420
Number of pages3
JournalScience
Volume276
Issue number5317
DOIs
StatePublished - May 30 1997

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Interferon alpha-beta Receptor
Phosphatidylinositol 3-Kinase
Interferon Receptors
Tyrosine
Phosphorylation
STAT Transcription Factors
STAT3 Transcription Factor
Acute-Phase Reaction
Conserved Sequence
Protein-Serine-Threonine Kinases
Serine
Signal Transduction
Cytokines
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. / Pfeffer, Lawrence; Mullersman, Jerald E.; Pfeffer, Susan R.; Murti, Aruna; Shi, Wei; Yang, Chuan.

In: Science, Vol. 276, No. 5317, 30.05.1997, p. 1418-1420.

Research output: Contribution to journalArticle

Pfeffer, Lawrence ; Mullersman, Jerald E. ; Pfeffer, Susan R. ; Murti, Aruna ; Shi, Wei ; Yang, Chuan. / STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. In: Science. 1997 ; Vol. 276, No. 5317. pp. 1418-1420.
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