Statins and cerebral hemodynamics

Sotirios Giannopoulos, Aristeidis H. Katsanos, Georgios Tsivgoulis, Randolph S. Marshall

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

HMG-CoA reductase inhibitors (statins) are associated with improved stroke outcome. This observation has been attributed in part to the palliative effect of statins on cerebral hemodynamics and cerebral autoregulation (CA), which are mediated mainly through the upregulation of endothelium nitric oxide synthase (eNOS). Several animal studies indicate that statin pretreatment enhances cerebral blood flow after ischemic stroke, although this finding is not further supported in clinical settings. Cerebral vasomotor reactivity, however, is significantly improved after long-term statin administration in most patients with severe small vessel disease, aneurysmal subarachnoid hemorrhage, or impaired baseline CA.

Original languageEnglish (US)
Pages (from-to)1973-1976
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hemodynamics
Cerebrovascular Circulation
Homeostasis
Stroke
Subarachnoid Hemorrhage
Nitric Oxide Synthase
Endothelium
Up-Regulation

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Statins and cerebral hemodynamics. / Giannopoulos, Sotirios; Katsanos, Aristeidis H.; Tsivgoulis, Georgios; Marshall, Randolph S.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 11, 01.11.2012, p. 1973-1976.

Research output: Contribution to journalReview article

Giannopoulos, S, Katsanos, AH, Tsivgoulis, G & Marshall, RS 2012, 'Statins and cerebral hemodynamics', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 11, pp. 1973-1976. https://doi.org/10.1038/jcbfm.2012.122
Giannopoulos, Sotirios ; Katsanos, Aristeidis H. ; Tsivgoulis, Georgios ; Marshall, Randolph S. / Statins and cerebral hemodynamics. In: Journal of Cerebral Blood Flow and Metabolism. 2012 ; Vol. 32, No. 11. pp. 1973-1976.
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