Status of B-Vitamins and homocysteine in diabetic retinopathy

Association with Vitamin-B12 deficiency and hyperhomocysteinemia

Satyanarayana Alleboina, Nagalla Balakrishna, Sujatha Pitla, Paduru Yadagiri Reddy, Sivaprasad Mudili, Pratti Lopamudra, Palla Suryanarayana, Kalluru Viswanath, Radha Ayyagari, Geereddy Bhanuprakash Reddy

Research output: Contribution to journalArticle

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Abstract

Diabetic retinopathy (DR) is a common cause of blindness. Although many studies have indicated an association between homocysteine and DR, the results so far have been equivocal. Amongst the many determinants of homocysteine, B-vitamin status was shown to be a major confounding factor, yet very little is known about its relationship to DR. In the present study, we, therefore, investigated the status of B-vitamins and homocysteine in DR. A cross-sectional case-control study was conducted with 100 normal control (CN) subjects and 300 subjects with type-2 diabetes (T2D). Of the 300 subjects with T2D, 200 had retinopathy (DR) and 100 did not (DNR). After a complete ophthalmic examination including fundus fluorescein angiography, the clinical profile and the blood levels of all B-vitamins and homocysteine were analyzed. While mean plasma homocysteine levels were found to be higher in T2D patients compared with CN subjects, homocysteine levels were particularly high in the DR group. There were no group differences in the blood levels of vitamins B1 and B2. Although the plasma vitamin-B6 and folic acid levels were significantly lower in the DNR and DR groups compared with the CN group, there were no significant differences between the diabetes groups. Interestingly, plasma vitamin-B12 levels were found to be significantly lower in the diabetes groups compared with the CN group; further, the levels were significantly lower in the DR group compared with the DNR group. Higher homocysteine levels were significantly associated with lower vitamin-B12 and folic acid but not with other B-vitamins. Additionally, hyperhomocysteinemia and vitamin-B12 deficiency did not seem to be related to subjects' age, body mass index, or duration of diabetes. These results thus suggest a possible association between vitamin-B12 deficiency and hyperhomocysteinemia in DR. Further, the data indicate that vitamin-B12 deficiency could be an independent risk factor for DR.

Original languageEnglish (US)
Article numbere26747
JournalPloS one
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2011

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diabetic retinopathy
Vitamin B 12 Deficiency
Vitamin B Complex
Hyperhomocysteinemia
vitamin B complex
homocysteine
Homocysteine
Diabetic Retinopathy
vitamin B12
Vitamin B 12
Medical problems
noninsulin-dependent diabetes mellitus
Plasmas
Folic Acid
Type 2 Diabetes Mellitus
diabetes
Blood
folic acid
Vitamin B 6
Angiography

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Status of B-Vitamins and homocysteine in diabetic retinopathy : Association with Vitamin-B12 deficiency and hyperhomocysteinemia. / Alleboina, Satyanarayana; Balakrishna, Nagalla; Pitla, Sujatha; Reddy, Paduru Yadagiri; Mudili, Sivaprasad; Lopamudra, Pratti; Suryanarayana, Palla; Viswanath, Kalluru; Ayyagari, Radha; Reddy, Geereddy Bhanuprakash.

In: PloS one, Vol. 6, No. 11, e26747, 01.11.2011.

Research output: Contribution to journalArticle

Alleboina, S, Balakrishna, N, Pitla, S, Reddy, PY, Mudili, S, Lopamudra, P, Suryanarayana, P, Viswanath, K, Ayyagari, R & Reddy, GB 2011, 'Status of B-Vitamins and homocysteine in diabetic retinopathy: Association with Vitamin-B12 deficiency and hyperhomocysteinemia', PloS one, vol. 6, no. 11, e26747. https://doi.org/10.1371/journal.pone.0026747
Alleboina, Satyanarayana ; Balakrishna, Nagalla ; Pitla, Sujatha ; Reddy, Paduru Yadagiri ; Mudili, Sivaprasad ; Lopamudra, Pratti ; Suryanarayana, Palla ; Viswanath, Kalluru ; Ayyagari, Radha ; Reddy, Geereddy Bhanuprakash. / Status of B-Vitamins and homocysteine in diabetic retinopathy : Association with Vitamin-B12 deficiency and hyperhomocysteinemia. In: PloS one. 2011 ; Vol. 6, No. 11.
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AU - Lopamudra, Pratti

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