Steady-state pleural fluid flow and pressure and the effects of lung buoyancy

R. Haber, J. B. Grotberg, M. R. Glucksberg, G. Miserocchi, D. Venturoli, M. Del Fabbro, C. M. Waters

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Both theoretical and experimental studies of pleural fluid dynamics and lung buoyancy during steady-state, apneic conditions are presented. The theory shows that steady-state, top-to-bottom pleural-liquid flow creates a pressure distribution that opposes lung buoyancy. These two forces may balance, permitting dynamic lung floating, but when they do not, pleural-pleural contact is required. The animal experiments examine pleural-liquid pressure distributions in response to simulated reduced gravity, achieved by lung inflation with perfluorocarbon liquid as compared to air. The resulting decrease in lung buoyancy modifies the force balance in the pleural fluid, which is reflected in its vertical pressure gradient. The data and model show that the decrease in buoyancy with perfluorocarbon inflation causes the vertical pressure gradient to approach hydrostatic. In the microgravity analogue, the pleural pressures would be toward a more uniform distribution, consistent with ventilation studies during space flight. The pleural liquid turnover predicted by the model is computed and found to be comparable to experimental values from the literature. The model provides the flow field, which can be used to develop a full transport theory for molecular and cellular constituents that are found in pleural fluid.

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalJournal of Biomechanical Engineering
Volume123
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Buoyancy
Flow of fluids
Pressure
Lung
Liquids
Fluorocarbons
Pressure gradient
Pressure distribution
Economic Inflation
Hypogravity
Fluids
Microgravity
Space flight
Fluid dynamics
Weightlessness
Space Flight
Ventilation
Hydrodynamics
Flow fields
Gravitation

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Haber, R., Grotberg, J. B., Glucksberg, M. R., Miserocchi, G., Venturoli, D., Del Fabbro, M., & Waters, C. M. (2001). Steady-state pleural fluid flow and pressure and the effects of lung buoyancy. Journal of Biomechanical Engineering, 123(5), 485-492. https://doi.org/10.1115/1.1392317

Steady-state pleural fluid flow and pressure and the effects of lung buoyancy. / Haber, R.; Grotberg, J. B.; Glucksberg, M. R.; Miserocchi, G.; Venturoli, D.; Del Fabbro, M.; Waters, C. M.

In: Journal of Biomechanical Engineering, Vol. 123, No. 5, 2001, p. 485-492.

Research output: Contribution to journalArticle

Haber, R, Grotberg, JB, Glucksberg, MR, Miserocchi, G, Venturoli, D, Del Fabbro, M & Waters, CM 2001, 'Steady-state pleural fluid flow and pressure and the effects of lung buoyancy', Journal of Biomechanical Engineering, vol. 123, no. 5, pp. 485-492. https://doi.org/10.1115/1.1392317
Haber R, Grotberg JB, Glucksberg MR, Miserocchi G, Venturoli D, Del Fabbro M et al. Steady-state pleural fluid flow and pressure and the effects of lung buoyancy. Journal of Biomechanical Engineering. 2001;123(5):485-492. https://doi.org/10.1115/1.1392317
Haber, R. ; Grotberg, J. B. ; Glucksberg, M. R. ; Miserocchi, G. ; Venturoli, D. ; Del Fabbro, M. ; Waters, C. M. / Steady-state pleural fluid flow and pressure and the effects of lung buoyancy. In: Journal of Biomechanical Engineering. 2001 ; Vol. 123, No. 5. pp. 485-492.
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