Steroid receptor concentration in aged rat hindlimb muscle

Effect of anabolic steroid administration

James Carson, Won Jun Lee, Joseph McClung, Gregory A. Hand

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Skeletal muscle is a target of anabolic steroid action; however, anabolic steroid's affect on aged skeletal muscle is not well understood. The effect of 4 wk of nandrolone decanoate (ND) administration on hindlimb muscles of 5- and 25-mo-old Fischer 344/Brown Norway rats was examined. ND (6 mg/kg body wt) was injected every 7th day for 4 wk. Controls received an oil injection. ND significantly reduced 25-mo-old rat perirenal fat pad mass by 30%. Soleus (Sol) and plantaris (Plan) muscle-to-body weight ratios were reduced in 25-mo-old rats. ND did not affect Sol or Plan muscle-to-body weight ratios at either age. Sol DNA concentration was reduced by 25% in 25-mo-old rats, and ND increased it to 12% greater than 5-mo-old rats. ND did not affect Plan DNA content. Sol androgen receptor (AR) protein in 25-mo-old rats was reduced to 35% of 5-mo-old values. ND increased AR protein by 900% in 25-mo-old rat Sol. Plan AR concentration was not affected by aging but was induced by ND in both age groups. Aging or ND treatment did not affect glucocorticoid receptor levels in either muscle. These data demonstrate that fast- and slow-twitch rat hindlimb muscles differ in their response to aging and ND therapy.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalJournal of Applied Physiology
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Testosterone Congeners
Steroid Receptors
Hindlimb
Muscles
Skeletal Muscle
Androgen Receptors
Body Weight
nandrolone decanoate
DNA
Glucocorticoid Receptors
Adipose Tissue
Oils
Proteins
Age Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Steroid receptor concentration in aged rat hindlimb muscle : Effect of anabolic steroid administration. / Carson, James; Lee, Won Jun; McClung, Joseph; Hand, Gregory A.

In: Journal of Applied Physiology, Vol. 93, No. 1, 01.01.2002, p. 242-250.

Research output: Contribution to journalArticle

Carson, James ; Lee, Won Jun ; McClung, Joseph ; Hand, Gregory A. / Steroid receptor concentration in aged rat hindlimb muscle : Effect of anabolic steroid administration. In: Journal of Applied Physiology. 2002 ; Vol. 93, No. 1. pp. 242-250.
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