Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve

S. Charpak, William Armstrong, M. Mühlethaler, J. J. Dreifuss

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve (DMX) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10-7 M or 10-6 M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalBrain Research
Volume300
Issue number1
DOIs
StatePublished - May 21 1984
Externally publishedYes

Fingerprint

Vagus Nerve
Motor Neurons
Oxytocin
Oxytocics
Posterior Pituitary Hormones
Oxytocin Receptors
Neurons
Vasopressins
Baths
Brain Stem

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. / Charpak, S.; Armstrong, William; Mühlethaler, M.; Dreifuss, J. J.

In: Brain Research, Vol. 300, No. 1, 21.05.1984, p. 83-89.

Research output: Contribution to journalArticle

Charpak, S. ; Armstrong, William ; Mühlethaler, M. ; Dreifuss, J. J. / Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. In: Brain Research. 1984 ; Vol. 300, No. 1. pp. 83-89.
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