Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen

D. E. Briles, M. Nahm, Tony Marion, R. M. Perlmutter, J. M. Davie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Streptococcal group A carbohydrate, which elicits mouse antibody of primarily the IgM and IgG3 isotypes, is relatively nonimmunogenic in nu/nu or xid mice, and thus appears to be a type of TD-2 antigen. The TD-2 antigens described previously have been proteins that elicit IgG antibody primarily of the IgG1 and IgG2 isotypes. Our findings indicate that TD-2 properties may also be a characteristic of at least some carbohydrate antigens that can elicit IgG antibody predominantly of the IgG3 class.

Original languageEnglish (US)
Pages (from-to)2032-2035
Number of pages4
JournalJournal of Immunology
Volume128
Issue number5
StatePublished - 1982
Externally publishedYes

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Thymus Gland
Immunoglobulin G
Antigens
Antibodies
Immunoglobulin M
streptococcal polysaccharide group A
Carbohydrates
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. / Briles, D. E.; Nahm, M.; Marion, Tony; Perlmutter, R. M.; Davie, J. M.

In: Journal of Immunology, Vol. 128, No. 5, 1982, p. 2032-2035.

Research output: Contribution to journalArticle

Briles, D. E. ; Nahm, M. ; Marion, Tony ; Perlmutter, R. M. ; Davie, J. M. / Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. In: Journal of Immunology. 1982 ; Vol. 128, No. 5. pp. 2032-2035.
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