Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after ischemia

Thaddeus Nowak, Olive C. Osborne, Sadao Suga

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

This chapter focuses on results obtained in studies of the expression of hsp70 as well as the transcription factors Fos and Jun following transient global ischemia, examining both the induction of the mRNAs and the synthesis of the encoded proteins. Current results obtained in the gerbil bilateral carotid artery occlusion model are consistent with the suggestion that translational recovery plays an important role in determining the accumulation of proteins encoded by induced mRNAs in specific neuron populations. These studies begin to define conditions of prior stress that can give rise to a given functional response, and thereby provide basic information necessary for a rational approach to studies of induced ischemic tolerance. The demonstrated increase of Jun-like immunoreactivity in CA1 neurons following brief ischemia suggests that complex cascades of altered gene expression initiated by priming insults are likely to contribute to any observed protection. Induction of hsp70 mRNA and protein appear to provide useful markers for delineating stages in the progression of neuronal pathophysiology after ischemia.

Original languageEnglish (US)
Pages (from-to)195-208
Number of pages14
JournalProgress in Brain Research
Volume96
Issue numberC
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Proto-Oncogenes
Heat-Shock Proteins
Ischemia
Messenger RNA
Neurons
Proteins
Gerbillinae
Carotid Arteries
Transcription Factors
Gene Expression
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after ischemia. / Nowak, Thaddeus; Osborne, Olive C.; Suga, Sadao.

In: Progress in Brain Research, Vol. 96, No. C, 01.01.1993, p. 195-208.

Research output: Contribution to journalArticle

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