Structural remodelling of the heart by fibrous tissue

Role of circulating hormones and locally produced peptides

Karl Weber, Yao Sun, S. E. Campbell

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Symptomatic heart failure is accompanied by diastolic ventricular dysfunction due largely to an extensive reactive and reparative fibrosis. Experimental evidence suggest a clear association between myocardial fibrosis and chronic inappropriate elevations in circulating angiotensin II (Ang II) and/or aldosterone. Although not entirely elucidated, injury follows Ang II-associated release of adrenal medullary catecholamines and aldosterone-induced myocardial potassium depletion. Increasing evidence indicates locally produced cardiac Ang II plays an important role in tissue repair that may underlie myocardial remodelling, the fibrous tissue accumulation both at and remote to the site of myocardial infraction (MI). Angiotensin converting enzyme (ACE) binding density markedly increases at these fibrous tissue sites after experimental MI, indicating an involvement in would healing regardless of the cause and location of fibrosis; cells expressing Ang II receptors are primarily myofibroblasts. Therapy with ACE inhibitors and aldosterone receptor antagonist have each been shown to attenuate development of fibrosis.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. N
StatePublished - 1995
Externally publishedYes

Fingerprint

Fibrosis
Angiotensin II
Hormones
Peptides
Aldosterone
Mineralocorticoid Receptor Antagonists
Ventricular Dysfunction
Angiotensin Receptors
Myofibroblasts
Peptidyl-Dipeptidase A
Angiotensin-Converting Enzyme Inhibitors
Catecholamines
Potassium
Heart Failure
Wounds and Injuries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Structural remodelling of the heart by fibrous tissue : Role of circulating hormones and locally produced peptides. / Weber, Karl; Sun, Yao; Campbell, S. E.

In: European Heart Journal, Vol. 16, No. SUPPL. N, 1995, p. 12-18.

Research output: Contribution to journalArticle

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