Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield

Toya D.H. Kimble, Robert Williams

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have analyzed variation in the structure of the human photoreceptor mosaic as a function of age, sex, and retinal location using the nearest neighbor and density recovery profile methods. In contrast to most previous work, we have focused our analysis on the mid- and far-peripheral human retina. Video-enhanced differential interference contrast optics was used to characterize differences in the nasal and temporal periphery of unstained wholemounts from 12 males and 12 females ranging in age from 15- to 83-years-old. At sites matched for cone density (~ 5000 cones/mm2), the mosaic is far more orderly in the temporal than in the nasal periphery. This is true at all ages and in both sexes. Despite their increased local order, regularity ratios of adjacent temporal fields tend to be much more variable than are those of adjacent nasal fields. These marked nasal-temporal differences are eliminated when eccentricity is held constant and cone density is allowed to vary. There is a mild, statistically significant age-related decline in the regularity of the cone mosaic, but only in the nasal periphery. There are no significant differences in the precision of the cone mosaic between sexes. The equivalence of the regularity of the mosaic at matched eccentricities, but not at matched cone densities, suggests that the irregularity of the mosaic is secondary to developmental gradients and, more generally, to reduced selection for high acuity vision in the retinal periphery.

Original languageEnglish (US)
Pages (from-to)305-316
Number of pages12
JournalAnatomy and Embryology
Volume201
Issue number4
DOIs
StatePublished - Jan 1 2000

Fingerprint

Retinal Cone Photoreceptor Cells
Nose
Retina

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Embryology
  • Developmental Biology
  • Cell Biology

Cite this

Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans : Analysis as a function of age, sex, and hemifield. / Kimble, Toya D.H.; Williams, Robert.

In: Anatomy and Embryology, Vol. 201, No. 4, 01.01.2000, p. 305-316.

Research output: Contribution to journalArticle

@article{9f30a89f47534ab183446be74dffb0d1,
title = "Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield",
abstract = "We have analyzed variation in the structure of the human photoreceptor mosaic as a function of age, sex, and retinal location using the nearest neighbor and density recovery profile methods. In contrast to most previous work, we have focused our analysis on the mid- and far-peripheral human retina. Video-enhanced differential interference contrast optics was used to characterize differences in the nasal and temporal periphery of unstained wholemounts from 12 males and 12 females ranging in age from 15- to 83-years-old. At sites matched for cone density (~ 5000 cones/mm2), the mosaic is far more orderly in the temporal than in the nasal periphery. This is true at all ages and in both sexes. Despite their increased local order, regularity ratios of adjacent temporal fields tend to be much more variable than are those of adjacent nasal fields. These marked nasal-temporal differences are eliminated when eccentricity is held constant and cone density is allowed to vary. There is a mild, statistically significant age-related decline in the regularity of the cone mosaic, but only in the nasal periphery. There are no significant differences in the precision of the cone mosaic between sexes. The equivalence of the regularity of the mosaic at matched eccentricities, but not at matched cone densities, suggests that the irregularity of the mosaic is secondary to developmental gradients and, more generally, to reduced selection for high acuity vision in the retinal periphery.",
author = "Kimble, {Toya D.H.} and Robert Williams",
year = "2000",
month = "1",
day = "1",
doi = "10.1007/s004290050319",
language = "English (US)",
volume = "201",
pages = "305--316",
journal = "Anatomische Hefte",
issn = "0177-5154",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans

T2 - Analysis as a function of age, sex, and hemifield

AU - Kimble, Toya D.H.

AU - Williams, Robert

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We have analyzed variation in the structure of the human photoreceptor mosaic as a function of age, sex, and retinal location using the nearest neighbor and density recovery profile methods. In contrast to most previous work, we have focused our analysis on the mid- and far-peripheral human retina. Video-enhanced differential interference contrast optics was used to characterize differences in the nasal and temporal periphery of unstained wholemounts from 12 males and 12 females ranging in age from 15- to 83-years-old. At sites matched for cone density (~ 5000 cones/mm2), the mosaic is far more orderly in the temporal than in the nasal periphery. This is true at all ages and in both sexes. Despite their increased local order, regularity ratios of adjacent temporal fields tend to be much more variable than are those of adjacent nasal fields. These marked nasal-temporal differences are eliminated when eccentricity is held constant and cone density is allowed to vary. There is a mild, statistically significant age-related decline in the regularity of the cone mosaic, but only in the nasal periphery. There are no significant differences in the precision of the cone mosaic between sexes. The equivalence of the regularity of the mosaic at matched eccentricities, but not at matched cone densities, suggests that the irregularity of the mosaic is secondary to developmental gradients and, more generally, to reduced selection for high acuity vision in the retinal periphery.

AB - We have analyzed variation in the structure of the human photoreceptor mosaic as a function of age, sex, and retinal location using the nearest neighbor and density recovery profile methods. In contrast to most previous work, we have focused our analysis on the mid- and far-peripheral human retina. Video-enhanced differential interference contrast optics was used to characterize differences in the nasal and temporal periphery of unstained wholemounts from 12 males and 12 females ranging in age from 15- to 83-years-old. At sites matched for cone density (~ 5000 cones/mm2), the mosaic is far more orderly in the temporal than in the nasal periphery. This is true at all ages and in both sexes. Despite their increased local order, regularity ratios of adjacent temporal fields tend to be much more variable than are those of adjacent nasal fields. These marked nasal-temporal differences are eliminated when eccentricity is held constant and cone density is allowed to vary. There is a mild, statistically significant age-related decline in the regularity of the cone mosaic, but only in the nasal periphery. There are no significant differences in the precision of the cone mosaic between sexes. The equivalence of the regularity of the mosaic at matched eccentricities, but not at matched cone densities, suggests that the irregularity of the mosaic is secondary to developmental gradients and, more generally, to reduced selection for high acuity vision in the retinal periphery.

UR - http://www.scopus.com/inward/record.url?scp=0034072628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034072628&partnerID=8YFLogxK

U2 - 10.1007/s004290050319

DO - 10.1007/s004290050319

M3 - Article

C2 - 10794170

AN - SCOPUS:0034072628

VL - 201

SP - 305

EP - 316

JO - Anatomische Hefte

JF - Anatomische Hefte

SN - 0177-5154

IS - 4

ER -