Structure of the human interferon α receptor

Oscar R. Colamonici, Lawrence Pfeffer

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The structure of the IFNα receptor has been studied by methods such as affinity crosslinking and gel chromatography over the last 8 years. The recent development of monoclonal antibodies against the receptor, and the cloning of an IFNα receptor cDNA has provided new important tools to understand the IFNα receptor structure. Thus, it has become obvious that the IFNα receptor has a more complex structure than first anticipated, probably involving more than one subunit. This review analyzes the present knowledge about the structure of the IFNα receptor, as well as many unresolved issues concerning this topic.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalPharmacology and Therapeutics
Volume52
Issue number2
DOIs
StatePublished - Jan 1 1991

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Interferon Receptors
Affinity Chromatography
Gel Chromatography
Organism Cloning
Complementary DNA
Monoclonal Antibodies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Structure of the human interferon α receptor. / Colamonici, Oscar R.; Pfeffer, Lawrence.

In: Pharmacology and Therapeutics, Vol. 52, No. 2, 01.01.1991, p. 227-233.

Research output: Contribution to journalArticle

Colamonici, Oscar R. ; Pfeffer, Lawrence. / Structure of the human interferon α receptor. In: Pharmacology and Therapeutics. 1991 ; Vol. 52, No. 2. pp. 227-233.
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