Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects

Teizo Ito, Peter Eggena, Jack D. Barrett, David Katz, E. Metter, Mohinder P. Sambhi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The presence of a renln-angiotensin system in the central nervous system (CNS) has been demonstrated by several investigators, but little is known regarding the origin of its components. In this study we have compared the immunological and physical-chemical nature of angiotensinogen in plasma and cerebrospinal fluid (CSF) of human subjects and explored whether differences are present in CSF angiotensinogen concentrations of normal and hypertensive subjects. No significant differences in the nature of plasma and CSF angiotensinogen was observed with respect to molecular weight (65-70,000) electrophoretic mobility (Rfaib - 0.67 ± 0.003) or angiotensin I (AI) generated (pi = 6.6). Following isoelectric focusing, the plasma angiotensinogen was shown to consist of a single component with an isoionic point of 4.40 ± 0.04. CSF angiotensinogen, on the other hand, resolved into three components (pi = 4.76 ± 0.02; 5.16 ± 0.04; 5.76 ± 0.04). Although no correlations were observed between angiotensinogen levels in the CSF or plasma with blood pressure (BP), a statistically significant difference in angiotensinogen concentration of both plasma and CSF was observed between normotensive and hypertensive subjects. The differences in the chemical and immunological nature of human plasma and CSF angiotensinogens suggest that the angiotensinogen of CSF is not of peripheral origin.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalHypertension
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Angiotensinogen
Cerebrospinal Fluid
Angiotensin I
Angiotensins
Isoelectric Focusing
Central Nervous System
Molecular Weight
Research Personnel
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects. / Ito, Teizo; Eggena, Peter; Barrett, Jack D.; Katz, David; Metter, E.; Sambhi, Mohinder P.

In: Hypertension, Vol. 2, No. 4, 01.01.1980, p. 432-436.

Research output: Contribution to journalArticle

Ito, Teizo ; Eggena, Peter ; Barrett, Jack D. ; Katz, David ; Metter, E. ; Sambhi, Mohinder P. / Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects. In: Hypertension. 1980 ; Vol. 2, No. 4. pp. 432-436.
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