Studies on itraconazole delivery and pharmacokinetics in mallard ducks (Anas platyrhynchos)

Lisa A. Tell, A. L. Craigmill, K. V. Clemons, Y. Sun, Steven Laizure, A. Clifford, J. H. Ina, J. P. Nugent-Deal, L. Woods, D. A. Stevens

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Avian aspergillosis is commonly treated with itraconazole (ITZ). This paper describes two studies using mallard ducks (Anas platyrhynchos). The first study evaluated in vivo release of ITZ from subcutaneously injected controlled-release gel formulations and the second study compared pharmacokinetic parameters for two ITZ oral suspensions. ITZ-A suspension was prepared by mixing contents of commercially available capsules with hydrochloric acid and orange juice. ITZ-B suspension was prepared by dispersing the complex of the drug with hydroxypropyl-β-cyclodextrin in water. Concentrations of ITZ and its active metabolite, hydroxyitraconazole (OH-ITZ), in plasma and tissue samples were measured using high-performance liquid chromatography. In the second study, drug concentrations in plasma samples were also analyzed using a bioassay. After administration of two ITZ controlled-release formulations, plasma and tissue concentrations of ITZ and OH-ITZ were either very low (≤52 ng/mL) or undetectable. Exceptions included skin, subcutaneous fat, and muscle adjacent to the injection site. The drug from ITZ-A and ITZ-B suspensions was absorbed after oral administration. ITZ pharmacokinetic parameters for both suspensions in mallard ducks were similar and the bioassay successfully measured ITZ equivalents in plasma samples from ducks.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume28
Issue number3
DOIs
StatePublished - Jun 1 2005

Fingerprint

Itraconazole
itraconazole
Ducks
Anas platyrhynchos
ducks
pharmacokinetics
Pharmacokinetics
Suspensions
drugs
Biological Assay
bioassays
Pharmaceutical Preparations
cyclodextrins
Aspergillosis
aspergillosis
Hydrochloric Acid
injection site
Subcutaneous Fat
hydrochloric acid
orange juice

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • veterinary(all)

Cite this

Studies on itraconazole delivery and pharmacokinetics in mallard ducks (Anas platyrhynchos). / Tell, Lisa A.; Craigmill, A. L.; Clemons, K. V.; Sun, Y.; Laizure, Steven; Clifford, A.; Ina, J. H.; Nugent-Deal, J. P.; Woods, L.; Stevens, D. A.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 28, No. 3, 01.06.2005, p. 267-274.

Research output: Contribution to journalArticle

Tell, LA, Craigmill, AL, Clemons, KV, Sun, Y, Laizure, S, Clifford, A, Ina, JH, Nugent-Deal, JP, Woods, L & Stevens, DA 2005, 'Studies on itraconazole delivery and pharmacokinetics in mallard ducks (Anas platyrhynchos)', Journal of Veterinary Pharmacology and Therapeutics, vol. 28, no. 3, pp. 267-274. https://doi.org/10.1111/j.1365-2885.2005.00656.x
Tell, Lisa A. ; Craigmill, A. L. ; Clemons, K. V. ; Sun, Y. ; Laizure, Steven ; Clifford, A. ; Ina, J. H. ; Nugent-Deal, J. P. ; Woods, L. ; Stevens, D. A. / Studies on itraconazole delivery and pharmacokinetics in mallard ducks (Anas platyrhynchos). In: Journal of Veterinary Pharmacology and Therapeutics. 2005 ; Vol. 28, No. 3. pp. 267-274.
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