Studies on the mechanism of ethambutol‐induced hyperuricemia

Arnold Postlethwaite, William N. Kelley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of ethambutol on uric acid metabolism was assessed in 14 patients, 8 with gout and 6 with tuberculosis. This antituberculous agent produces hyperuricemia by decreasing the renal clearance of uric acid. Although the exact mechanism responsible for this effect of ethambutol remains undefined, several characteristics were observed which distinguish the effect of this drug from that of other agents which produce hyperuricemia by altering the renal handling of uric acid.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalArthritis & Rheumatism
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1972

Fingerprint

Hyperuricemia
Uric Acid
Ethambutol
Kidney
Gout
Tuberculosis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Studies on the mechanism of ethambutol‐induced hyperuricemia. / Postlethwaite, Arnold; Kelley, William N.

In: Arthritis & Rheumatism, Vol. 15, No. 4, 01.01.1972, p. 403-409.

Research output: Contribution to journalArticle

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