Studies on the structure and organization of avian sarcoma proviruses in the rat XC cell line

S. A. Mitsialis, R. A. Katz, J. Svoboda, Ramareddy Guntaka

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8 Citations (Scopus)

Abstract

The structure of arrangement of the multiple provirus copies of avian sarcoma virus in a rat XC cell line were studied by restriction endonucleases. The following observations were made: (i) the majority of the proviruses integrated randomly with respect to cell DNA; (ii) no gross deletions or rearrangements in the proviruses were observed; (iii) two types of proviruses (type I and type II) could be distinguished on the basis of restriction endonuclease cleavage sites; (iv) the virus rescued from these cells was derived from type II provirus, which as a novel EcoRI site between the env and pol genes; (v) most of the provirus units contained the src gene.

Original languageEnglish (US)
Pages (from-to)1885-1893
Number of pages9
JournalJournal of General Virology
Volume64
Issue number9
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Avian Sarcoma
Proviruses
Cell Line
DNA Restriction Enzymes
Avian Sarcoma Viruses
src Genes
pol Genes
env Genes
Viruses
DNA

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Studies on the structure and organization of avian sarcoma proviruses in the rat XC cell line. / Mitsialis, S. A.; Katz, R. A.; Svoboda, J.; Guntaka, Ramareddy.

In: Journal of General Virology, Vol. 64, No. 9, 01.01.1983, p. 1885-1893.

Research output: Contribution to journalArticle

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