Subacute hepatitis in Waldenström's macroglobulinemia

Seymour Cohen, Alan Solomon, Fiorenzo Paronetto, Hans Popper

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A patient with primary macroglobulinemia, with characteristic organ manifestations, had subacute fatal hepatitis, apparently homologous serum jaundice. By fluorescence immunocytochemical technics, macroglobulins were demonstrated in plasma cells and in basophilic reticuloendothelial cells, the latter sometimes occurring as littoral cells of sinusoids of liver and spleen. Very few of these hepatic and splenic cells contained 7S gamma globulin (GG). The macroglobulin distribution in the liver corresponded to the distribution of 7S globulins in similar cases of subacute hepatitis in the absence of macroglobulinemia. This was interpreted to indicate that the macroglobulin-producing cells in the liver were reactive rather than neoplastic, immunologically competent cells. Casts in the distal convoluted renal tubules reacted with antibody to 19S macroglobulins but were probably cross reacting 2S globulins.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalThe American Journal of Medicine
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1963
Externally publishedYes

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Waldenstrom Macroglobulinemia
Macroglobulins
Hepatitis
Globulins
Liver
Distal Kidney Tubule
Jaundice
Plasma Cells
Hepatocytes
Spleen
Immunoglobulin G
Fluorescence
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Subacute hepatitis in Waldenström's macroglobulinemia. / Cohen, Seymour; Solomon, Alan; Paronetto, Fiorenzo; Popper, Hans.

In: The American Journal of Medicine, Vol. 34, No. 2, 01.01.1963, p. 256-263.

Research output: Contribution to journalArticle

Cohen, Seymour ; Solomon, Alan ; Paronetto, Fiorenzo ; Popper, Hans. / Subacute hepatitis in Waldenström's macroglobulinemia. In: The American Journal of Medicine. 1963 ; Vol. 34, No. 2. pp. 256-263.
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