Subacute Noradrenergic Agonist Infusions In Vivo Increase Na+, K+‐ATPase and Ouabain Binding in Rat Cerebral Cortex

Alan C. Swann, Jeffery Steketee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Abstract: In order to investigate the specificity of noradrenergic effects on Na+, K+‐ATPase, we infused noradrenergic agonists into the cerebral ventricles of rats, with or without depletion of forebrain norepinephrine. Infusion of norepinephrine, isoproterenol, or phenylephrine increased ouabain binding in intact rats, whereas clonidine infusion decreased binding. Depletion of forebrain norepinephrine by destruction of the dorsal noradrenergic bundle reduced ouabain binding. Norepinephrine infusion reversed the effect of dorsal bundle lesion; isoproterenol and phenylephrine increased ouabain binding in lesioned rats, but did not restore the effect of the lesions. Clonidine had no effect in lesioned rats. Effects on Na+,K+‐ATPase activity were similar, but smaller. These results suggest that stimulation of both α1‐ and β‐noradrenergic receptors may be necessary for optimal Na+,K+‐ATPase, and that clonidine reduces Na+,K+‐ATPase indirectly through decreased norepinephrine release.

Original languageEnglish (US)
Pages (from-to)1598-1604
Number of pages7
JournalJournal of Neurochemistry
Volume52
Issue number5
DOIs
StatePublished - Jan 1 1989

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Ouabain
Cerebral Cortex
Adenosine Triphosphatases
Rats
Norepinephrine
Clonidine
Phenylephrine
Prosencephalon
Isoproterenol
Cerebral Ventricles
sodium-translocating ATPase

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Subacute Noradrenergic Agonist Infusions In Vivo Increase Na+, K+‐ATPase and Ouabain Binding in Rat Cerebral Cortex. / Swann, Alan C.; Steketee, Jeffery.

In: Journal of Neurochemistry, Vol. 52, No. 5, 01.01.1989, p. 1598-1604.

Research output: Contribution to journalArticle

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