Subgroup analyses of randomized clinical trials in heart failure

facts and numbers

Andrija Vidic, John T. Chibnall, Niharika Goparaju, Paul Hauptman

Research output: Contribution to journalEditorial

3 Citations (Scopus)

Abstract

Subgroup analyses of major randomized clinical trials in heart failure are published frequently, but their impact on medical knowledge and practice guidelines has not been previously reported. In a novel analysis, we determined number of citations, impact factors, number of authors, and citations in guidelines of both parent trials and sub-studies; we also qualitatively assessed whether the analyses were described as post-hoc and non-pre-specified. A total of 229 sub-studies evaluating outcomes in patient subgroups were published (median 6, range 0–36 per trial). The number of subjects in the parent trials positively correlated with number of sub-studies (rho = 0.51, P = 0.009). The subgroups are frequently not pre-specified. The impact factors of sub-studies were lower in comparison to the parent trials as were the number of citations two years after the publication date; in addition, parent trials were cited more frequently in European and American professional guidelines compared with the sub-studies. We maintain that the sub-studies derived from major heart failure trials are frequently published, but their contribution to clinical guidelines and medical knowledge are highly debatable.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalESC Heart Failure
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Randomized Controlled Trials
Heart Failure
Guidelines
Practice Guidelines
Publications
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Subgroup analyses of randomized clinical trials in heart failure : facts and numbers. / Vidic, Andrija; Chibnall, John T.; Goparaju, Niharika; Hauptman, Paul.

In: ESC Heart Failure, Vol. 3, No. 3, 01.01.2016, p. 152-157.

Research output: Contribution to journalEditorial

Vidic, Andrija ; Chibnall, John T. ; Goparaju, Niharika ; Hauptman, Paul. / Subgroup analyses of randomized clinical trials in heart failure : facts and numbers. In: ESC Heart Failure. 2016 ; Vol. 3, No. 3. pp. 152-157.
@article{134cc23f3a72411d981d9c44936ea30c,
title = "Subgroup analyses of randomized clinical trials in heart failure: facts and numbers",
abstract = "Subgroup analyses of major randomized clinical trials in heart failure are published frequently, but their impact on medical knowledge and practice guidelines has not been previously reported. In a novel analysis, we determined number of citations, impact factors, number of authors, and citations in guidelines of both parent trials and sub-studies; we also qualitatively assessed whether the analyses were described as post-hoc and non-pre-specified. A total of 229 sub-studies evaluating outcomes in patient subgroups were published (median 6, range 0–36 per trial). The number of subjects in the parent trials positively correlated with number of sub-studies (rho = 0.51, P = 0.009). The subgroups are frequently not pre-specified. The impact factors of sub-studies were lower in comparison to the parent trials as were the number of citations two years after the publication date; in addition, parent trials were cited more frequently in European and American professional guidelines compared with the sub-studies. We maintain that the sub-studies derived from major heart failure trials are frequently published, but their contribution to clinical guidelines and medical knowledge are highly debatable.",
author = "Andrija Vidic and Chibnall, {John T.} and Niharika Goparaju and Paul Hauptman",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/ehf2.12093",
language = "English (US)",
volume = "3",
pages = "152--157",
journal = "ESC heart failure",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "3",

}

TY - JOUR

T1 - Subgroup analyses of randomized clinical trials in heart failure

T2 - facts and numbers

AU - Vidic, Andrija

AU - Chibnall, John T.

AU - Goparaju, Niharika

AU - Hauptman, Paul

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Subgroup analyses of major randomized clinical trials in heart failure are published frequently, but their impact on medical knowledge and practice guidelines has not been previously reported. In a novel analysis, we determined number of citations, impact factors, number of authors, and citations in guidelines of both parent trials and sub-studies; we also qualitatively assessed whether the analyses were described as post-hoc and non-pre-specified. A total of 229 sub-studies evaluating outcomes in patient subgroups were published (median 6, range 0–36 per trial). The number of subjects in the parent trials positively correlated with number of sub-studies (rho = 0.51, P = 0.009). The subgroups are frequently not pre-specified. The impact factors of sub-studies were lower in comparison to the parent trials as were the number of citations two years after the publication date; in addition, parent trials were cited more frequently in European and American professional guidelines compared with the sub-studies. We maintain that the sub-studies derived from major heart failure trials are frequently published, but their contribution to clinical guidelines and medical knowledge are highly debatable.

AB - Subgroup analyses of major randomized clinical trials in heart failure are published frequently, but their impact on medical knowledge and practice guidelines has not been previously reported. In a novel analysis, we determined number of citations, impact factors, number of authors, and citations in guidelines of both parent trials and sub-studies; we also qualitatively assessed whether the analyses were described as post-hoc and non-pre-specified. A total of 229 sub-studies evaluating outcomes in patient subgroups were published (median 6, range 0–36 per trial). The number of subjects in the parent trials positively correlated with number of sub-studies (rho = 0.51, P = 0.009). The subgroups are frequently not pre-specified. The impact factors of sub-studies were lower in comparison to the parent trials as were the number of citations two years after the publication date; in addition, parent trials were cited more frequently in European and American professional guidelines compared with the sub-studies. We maintain that the sub-studies derived from major heart failure trials are frequently published, but their contribution to clinical guidelines and medical knowledge are highly debatable.

UR - http://www.scopus.com/inward/record.url?scp=85042416164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042416164&partnerID=8YFLogxK

U2 - 10.1002/ehf2.12093

DO - 10.1002/ehf2.12093

M3 - Editorial

VL - 3

SP - 152

EP - 157

JO - ESC heart failure

JF - ESC heart failure

SN - 2055-5822

IS - 3

ER -