Submucosal nerve hypertrophy in congenital laryngomalacia

Patrick D. Munson, Ali Saad, Siraj M. El-Jamal, Yuemeng Dai, Charles M. Bower, Gresham T. Richter

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives/Hypothesis: To determine the neuropathologic findings in tissue obtained from children with laryngomalacia at a tertiary-care pediatric hospital. Study Design: Retrospective review of consecutive cohort compared with a control group. Methods: We reviewed supra-arytenoid pathology specimens from 43 children with severe laryngomalacia and 13 age-matched pediatric autopsy controls. Histopathologic comparison was made of nerve hypertrophy (including nerve perimeter and surface area) among experimental and control pathologic specimens. Results: There exists a statistically significant increase in nerve perimeter (P =.001) and nerve surface area (P =.02) in supra-arytenoid specimens in patients with severe laryngomalacia compared with age-matched autopsy supra-arytenoid tissue. Conclusions: The pathologic finding of nerve hypertrophy in children with laryngomalacia provides new evidence to support neurologic dysfunction as the etiologic theory of laryngomalacia.

Original languageEnglish (US)
Pages (from-to)627-629
Number of pages3
JournalLaryngoscope
Volume121
Issue number3
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

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Laryngomalacia
Hypertrophy
Autopsy
Pediatric Hospitals
Tertiary Healthcare
Neurologic Manifestations
Retrospective Studies
Pediatrics
Pathology
Control Groups

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Munson, P. D., Saad, A., El-Jamal, S. M., Dai, Y., Bower, C. M., & Richter, G. T. (2011). Submucosal nerve hypertrophy in congenital laryngomalacia. Laryngoscope, 121(3), 627-629. https://doi.org/10.1002/lary.21360

Submucosal nerve hypertrophy in congenital laryngomalacia. / Munson, Patrick D.; Saad, Ali; El-Jamal, Siraj M.; Dai, Yuemeng; Bower, Charles M.; Richter, Gresham T.

In: Laryngoscope, Vol. 121, No. 3, 01.03.2011, p. 627-629.

Research output: Contribution to journalArticle

Munson, PD, Saad, A, El-Jamal, SM, Dai, Y, Bower, CM & Richter, GT 2011, 'Submucosal nerve hypertrophy in congenital laryngomalacia', Laryngoscope, vol. 121, no. 3, pp. 627-629. https://doi.org/10.1002/lary.21360
Munson PD, Saad A, El-Jamal SM, Dai Y, Bower CM, Richter GT. Submucosal nerve hypertrophy in congenital laryngomalacia. Laryngoscope. 2011 Mar 1;121(3):627-629. https://doi.org/10.1002/lary.21360
Munson, Patrick D. ; Saad, Ali ; El-Jamal, Siraj M. ; Dai, Yuemeng ; Bower, Charles M. ; Richter, Gresham T. / Submucosal nerve hypertrophy in congenital laryngomalacia. In: Laryngoscope. 2011 ; Vol. 121, No. 3. pp. 627-629.
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