Substance P induces a cardiovascular defense reaction in the rat

Pharmacological characterization

T. Unger, S. Carolus, G. Demmert, D. Ganten, R. E. Lang, C. Maser-Gluth, Helmut Steinberg, R. Veelken

Research output: Contribution to journalArticle

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Abstract

In this study in conscious rats, we tested the hypothesis that substance P, a central pressor peptide and a potential transmitter substance of pain pathways, could be involved in the cardiovascular defense reaction that is typically associated with unpleasant sensory stimuli. The hemodynamic responses to centrally administered substance P were pharmacologically characterized. The increases in blood pressure and heart rate after intracerebroventricular injections of substance P were accompanied by mesenteric and renal vasoconstriction and hind limb vasodilation (pulsed-Doppler flow probes). The pressor and vasoconstrictor responses were attenuated by peripheral α 1 -adrenoceptor blockade with prazosin but were not influenced by blockade of vascular vasopressin receptors with d(CH 2 ) 5 Tyr(Me) arginine vasopressin (AVP). Cardiac β 1 -adrenoceptor blockade with metroprolol abolished the tachycardic and reduced the pressor responses. Substance P-induced hind limb vasodilation was not sensitive to intravenous atropine but was largely prevented by peripheral β 2 -adrenoceptor blockade with ICI 118,551. Thus, the substance P-induced pressor effects are mediated by α 1 -adrenergic sympathetic vasoconstriction and β 1 -adrenergic cardiac stimulation, whereas the hind limb vasodilation is mainly due to β 2 -adrenergic stimulation. Substance P dose-dependently (0.01-10 μg i.c.v.) released oxytocin but not vasopressin or adrenocorticotropic hormone (ACTH) from the pituitary gland. High doses reduced basal ACTH levels. Together with the hemodynamic responses, a behavioral arousal reaction was observed, which included increased locomotion, grooming, scratching, and skin bitting. Our results demonstrate that a neuropeptide can induce a classic cardiovascular defense reaction. The endocrine component of the substance P-induced response (oxytocin release) is compatible with stress reactions, and the behavioral component is compatible with the reaction to nociceptive stimuli in rodents. We conclude that in the central nervous system, subtance P may be important for the generation of an integrated cardiovascular and behavioral response pattern within the efferent pathways of the reaction to nociceptive stimuli.

Original languageEnglish (US)
Pages (from-to)812-820
Number of pages9
JournalCirculation research
Volume63
Issue number4
DOIs
StatePublished - Jan 1 1988

Fingerprint

Substance P
Pharmacology
Vasodilation
Adrenergic Agents
Adrenergic Receptors
Extremities
Oxytocin
Vasoconstriction
Adrenocorticotropic Hormone
Hemodynamics
Efferent Pathways
Vasopressin Receptors
Grooming
Arginine Vasopressin
Prazosin
Vasoconstrictor Agents
Pituitary Gland
Locomotion
Arousal
Neuropeptides

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Unger, T., Carolus, S., Demmert, G., Ganten, D., Lang, R. E., Maser-Gluth, C., ... Veelken, R. (1988). Substance P induces a cardiovascular defense reaction in the rat: Pharmacological characterization. Circulation research, 63(4), 812-820. https://doi.org/10.1161/01.RES.63.4.812

Substance P induces a cardiovascular defense reaction in the rat : Pharmacological characterization. / Unger, T.; Carolus, S.; Demmert, G.; Ganten, D.; Lang, R. E.; Maser-Gluth, C.; Steinberg, Helmut; Veelken, R.

In: Circulation research, Vol. 63, No. 4, 01.01.1988, p. 812-820.

Research output: Contribution to journalArticle

Unger, T, Carolus, S, Demmert, G, Ganten, D, Lang, RE, Maser-Gluth, C, Steinberg, H & Veelken, R 1988, 'Substance P induces a cardiovascular defense reaction in the rat: Pharmacological characterization', Circulation research, vol. 63, no. 4, pp. 812-820. https://doi.org/10.1161/01.RES.63.4.812
Unger, T. ; Carolus, S. ; Demmert, G. ; Ganten, D. ; Lang, R. E. ; Maser-Gluth, C. ; Steinberg, Helmut ; Veelken, R. / Substance P induces a cardiovascular defense reaction in the rat : Pharmacological characterization. In: Circulation research. 1988 ; Vol. 63, No. 4. pp. 812-820.
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