Sulotroban selectively inhibits thromboxane-receptor-mediated responses in the peripheral vascular bed of the cat

Peter Kvamme, R. K. Minkes, P. J. Kadowiz

Research output: Contribution to journalArticle

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Abstract

The effects of Sulotroban (BM 13.177, SK and F 95587) were investigated under conditions of controlled blood flow in the hindquarters and mesenteric vascular beds of the cat. Injections of the thromboxane (TX) A2 mimics, U46619 and U44069, caused dose-related increases in perfusion pressure. After administration of SK and F 95587, vasoconstrictor responses to the TXA2 mimics were reduced significantly, and the dose-response curves were shifted to the right in a parallel fashion. Responses to norepinephrine, phenylephrine, tyramine, endothelin-1, angiotensin II, BAY K8644, acetylcholine, sodium nitroprusside, isoproterenol, lemakalim, prostaglandin (PG) E1, and PGF(2α), agents which alter vascular resistance by a variety of mechanisms, were not changed by the TXA2 receptor antagonist. However, SK and F 95587 reduced mesenteric vasoconstrictor responses to PGD2. Results of the present study indicate that SK and F 95587 blocks TX-receptor-mediated responses in the hindquarters circulation of the cat in a competitive and selective manner and reduces mesenteric vascular responses to the TXA2 mimics, as well as PGD2. These data suggest that this antagonist would be useful in studies on the role of TXA2 in physiologic and pathophysiologic processes in the systemic vascular bed of the cat.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalEicosanoids
Volume5
Issue number3-4
StatePublished - Dec 1 1992
Externally publishedYes

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Thromboxane Receptors
Blood Vessels
Cats
Prostaglandin D2
Vasoconstrictor Agents
Cromakalim
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Tyramine
Thromboxane A2
Alprostadil
Prostaglandins F
Nitroprusside
Phenylephrine
Endothelin-1
Isoproterenol
Angiotensin II
Vascular Resistance
Acetylcholine
sulotroban
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

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Sulotroban selectively inhibits thromboxane-receptor-mediated responses in the peripheral vascular bed of the cat. / Kvamme, Peter; Minkes, R. K.; Kadowiz, P. J.

In: Eicosanoids, Vol. 5, No. 3-4, 01.12.1992, p. 127-133.

Research output: Contribution to journalArticle

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