Superficial siderosis of the central nervous system

K. Spengos, M. Panas, G. Koutsis, S. Sameli, Georgios Tsivgoulis, A. Petropoulou, D. Vassilopoulos

Research output: Contribution to journalArticle

Abstract

Superficial siderosis is a rare disease of the central nervous system, caused by destructive deposition of hemosiderin in the leptomeninges and the subpial layers of the brain and the spinal cord. This is the result of continuous or recurrent, often clinically silent, hemorrhage in the subarachnoid space, often without an evident bleeding source. The cases are described of two male patients with severe cerebellar ataxia, progressive bilateral sensorineural hearing loss, pyramidal tract signs and dementia. The diagnosis of superficial siderosis is supported by the characteristic symptom constellation, the xanthochromic cerebrospinal fluid (in one patient) and the typical MRI findings on the surface of the brainstem, cerebellum, cortex and spinal cord. Early recognition and treatment of this rare clinical entity may be of importance for the further prognosis of patients.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
JournalArchives of Hellenic Medicine
Volume21
Issue number6
StatePublished - Nov 1 2004

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Siderosis
Central Nervous System
Spinal Cord
Bilateral Hearing Loss
Hemorrhage
Hemosiderin
Cerebellar Ataxia
Subarachnoid Space
Pyramidal Tracts
Sensorineural Hearing Loss
Rare Diseases
Cerebellum
Brain Stem
Cerebrospinal Fluid
Dementia
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Spengos, K., Panas, M., Koutsis, G., Sameli, S., Tsivgoulis, G., Petropoulou, A., & Vassilopoulos, D. (2004). Superficial siderosis of the central nervous system. Archives of Hellenic Medicine, 21(6), 563-567.

Superficial siderosis of the central nervous system. / Spengos, K.; Panas, M.; Koutsis, G.; Sameli, S.; Tsivgoulis, Georgios; Petropoulou, A.; Vassilopoulos, D.

In: Archives of Hellenic Medicine, Vol. 21, No. 6, 01.11.2004, p. 563-567.

Research output: Contribution to journalArticle

Spengos, K, Panas, M, Koutsis, G, Sameli, S, Tsivgoulis, G, Petropoulou, A & Vassilopoulos, D 2004, 'Superficial siderosis of the central nervous system', Archives of Hellenic Medicine, vol. 21, no. 6, pp. 563-567.
Spengos K, Panas M, Koutsis G, Sameli S, Tsivgoulis G, Petropoulou A et al. Superficial siderosis of the central nervous system. Archives of Hellenic Medicine. 2004 Nov 1;21(6):563-567.
Spengos, K. ; Panas, M. ; Koutsis, G. ; Sameli, S. ; Tsivgoulis, Georgios ; Petropoulou, A. ; Vassilopoulos, D. / Superficial siderosis of the central nervous system. In: Archives of Hellenic Medicine. 2004 ; Vol. 21, No. 6. pp. 563-567.
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