Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin

Erzhen Duan, Dang Wang, Liurong Fang, Jun Ma, Jingyi Luo, Huanchun Chen, Kui Li, Shaobo Xiao

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalAntiviral Research
Volume120
DOIs
StatePublished - Jun 10 2015

Fingerprint

Glycyrrhizic Acid
Porcine respiratory and reproductive syndrome virus
Arterivirus
Porcine Reproductive and Respiratory Syndrome
Glycyrrhiza
Life Cycle Stages
Virion
Adsorption
Antiviral Agents
Industry
Swine

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Virology

Cite this

Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin. / Duan, Erzhen; Wang, Dang; Fang, Liurong; Ma, Jun; Luo, Jingyi; Chen, Huanchun; Li, Kui; Xiao, Shaobo.

In: Antiviral Research, Vol. 120, 10.06.2015, p. 122-125.

Research output: Contribution to journalArticle

Duan, Erzhen ; Wang, Dang ; Fang, Liurong ; Ma, Jun ; Luo, Jingyi ; Chen, Huanchun ; Li, Kui ; Xiao, Shaobo. / Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin. In: Antiviral Research. 2015 ; Vol. 120. pp. 122-125.
@article{cf51808de3ec48e8945dc7bc0eb28840,
title = "Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin",
abstract = "Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy.",
author = "Erzhen Duan and Dang Wang and Liurong Fang and Jun Ma and Jingyi Luo and Huanchun Chen and Kui Li and Shaobo Xiao",
year = "2015",
month = "6",
day = "10",
doi = "10.1016/j.antiviral.2015.06.001",
language = "English (US)",
volume = "120",
pages = "122--125",
journal = "Antiviral Research",
issn = "0166-3542",
publisher = "Elsevier",

}

TY - JOUR

T1 - Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin

AU - Duan, Erzhen

AU - Wang, Dang

AU - Fang, Liurong

AU - Ma, Jun

AU - Luo, Jingyi

AU - Chen, Huanchun

AU - Li, Kui

AU - Xiao, Shaobo

PY - 2015/6/10

Y1 - 2015/6/10

N2 - Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy.

AB - Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy.

UR - http://www.scopus.com/inward/record.url?scp=84930958421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930958421&partnerID=8YFLogxK

U2 - 10.1016/j.antiviral.2015.06.001

DO - 10.1016/j.antiviral.2015.06.001

M3 - Article

VL - 120

SP - 122

EP - 125

JO - Antiviral Research

JF - Antiviral Research

SN - 0166-3542

ER -