Surfactant-modified Poly(acrylamide-co-acrylamido propane sulphonic acid) hydrogels

S. Ravindra, Murali Yallapu, K. Varaprasad, N. Narayana Reddy, K. Vimala, K. Mohana Raju

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent advances in drug delivery have been directed towards the design of a number of intelligent systems for the treatment of various diseases. In this regard, we developed novel surfactant-modified hydrogels which are synthesized from acrylamide (AM) and acrylamido propane sulphonic acid (AMPS), in the presence of a surfactant (Latemul PD-104) using ammonium persulfate/N,N,N',N'- tetramethylethylene diamine (APS)/(TMEDA) as an initiating system and N,N'-methylenebisacrlyamide (MBA) as a crosslinker. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The variation in the hydrogel networks formation employing different levels of synthetic parameters was verified by swelling studies. Influences of salt, biological fluids, and buffer solutions on the developed systems were also investigated. It was found that, compared to PAM hydrogel, all the surfactant-modified hydrogels were responsive towards salt concentration and pH. A robust drug release behavior was observed from surfactant-modified hydrogel systems.

Original languageEnglish (US)
Pages (from-to)278-296
Number of pages19
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume58
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Propane
Hydrogels
Sulfonic Acids
Hydrogel
Polyacrylates
Surface-Active Agents
Surface active agents
Acids
Salts
Pulse amplitude modulation
Diamines
Acrylamide
Intelligent systems
Drug delivery
Swelling
Ammonium persulfate
Buffers
Scanning electron microscopy
Fourier transform infrared spectroscopy
Fluids

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

Cite this

Surfactant-modified Poly(acrylamide-co-acrylamido propane sulphonic acid) hydrogels. / Ravindra, S.; Yallapu, Murali; Varaprasad, K.; Reddy, N. Narayana; Vimala, K.; Raju, K. Mohana.

In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 58, No. 5, 01.05.2009, p. 278-296.

Research output: Contribution to journalArticle

Ravindra, S. ; Yallapu, Murali ; Varaprasad, K. ; Reddy, N. Narayana ; Vimala, K. ; Raju, K. Mohana. / Surfactant-modified Poly(acrylamide-co-acrylamido propane sulphonic acid) hydrogels. In: International Journal of Polymeric Materials and Polymeric Biomaterials. 2009 ; Vol. 58, No. 5. pp. 278-296.
@article{ad4cba6e2d074a23b2d98f50937d5f78,
title = "Surfactant-modified Poly(acrylamide-co-acrylamido propane sulphonic acid) hydrogels",
abstract = "Recent advances in drug delivery have been directed towards the design of a number of intelligent systems for the treatment of various diseases. In this regard, we developed novel surfactant-modified hydrogels which are synthesized from acrylamide (AM) and acrylamido propane sulphonic acid (AMPS), in the presence of a surfactant (Latemul PD-104) using ammonium persulfate/N,N,N',N'- tetramethylethylene diamine (APS)/(TMEDA) as an initiating system and N,N'-methylenebisacrlyamide (MBA) as a crosslinker. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The variation in the hydrogel networks formation employing different levels of synthetic parameters was verified by swelling studies. Influences of salt, biological fluids, and buffer solutions on the developed systems were also investigated. It was found that, compared to PAM hydrogel, all the surfactant-modified hydrogels were responsive towards salt concentration and pH. A robust drug release behavior was observed from surfactant-modified hydrogel systems.",
author = "S. Ravindra and Murali Yallapu and K. Varaprasad and Reddy, {N. Narayana} and K. Vimala and Raju, {K. Mohana}",
year = "2009",
month = "5",
day = "1",
doi = "10.1080/00914030902719568",
language = "English (US)",
volume = "58",
pages = "278--296",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
issn = "0091-4037",
publisher = "Taylor and Francis Ltd.",
number = "5",

}

TY - JOUR

T1 - Surfactant-modified Poly(acrylamide-co-acrylamido propane sulphonic acid) hydrogels

AU - Ravindra, S.

AU - Yallapu, Murali

AU - Varaprasad, K.

AU - Reddy, N. Narayana

AU - Vimala, K.

AU - Raju, K. Mohana

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Recent advances in drug delivery have been directed towards the design of a number of intelligent systems for the treatment of various diseases. In this regard, we developed novel surfactant-modified hydrogels which are synthesized from acrylamide (AM) and acrylamido propane sulphonic acid (AMPS), in the presence of a surfactant (Latemul PD-104) using ammonium persulfate/N,N,N',N'- tetramethylethylene diamine (APS)/(TMEDA) as an initiating system and N,N'-methylenebisacrlyamide (MBA) as a crosslinker. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The variation in the hydrogel networks formation employing different levels of synthetic parameters was verified by swelling studies. Influences of salt, biological fluids, and buffer solutions on the developed systems were also investigated. It was found that, compared to PAM hydrogel, all the surfactant-modified hydrogels were responsive towards salt concentration and pH. A robust drug release behavior was observed from surfactant-modified hydrogel systems.

AB - Recent advances in drug delivery have been directed towards the design of a number of intelligent systems for the treatment of various diseases. In this regard, we developed novel surfactant-modified hydrogels which are synthesized from acrylamide (AM) and acrylamido propane sulphonic acid (AMPS), in the presence of a surfactant (Latemul PD-104) using ammonium persulfate/N,N,N',N'- tetramethylethylene diamine (APS)/(TMEDA) as an initiating system and N,N'-methylenebisacrlyamide (MBA) as a crosslinker. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The variation in the hydrogel networks formation employing different levels of synthetic parameters was verified by swelling studies. Influences of salt, biological fluids, and buffer solutions on the developed systems were also investigated. It was found that, compared to PAM hydrogel, all the surfactant-modified hydrogels were responsive towards salt concentration and pH. A robust drug release behavior was observed from surfactant-modified hydrogel systems.

UR - http://www.scopus.com/inward/record.url?scp=61849087264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61849087264&partnerID=8YFLogxK

U2 - 10.1080/00914030902719568

DO - 10.1080/00914030902719568

M3 - Article

VL - 58

SP - 278

EP - 296

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

SN - 0091-4037

IS - 5

ER -