Surgical management and prognosis of renal cell carcinoma invading the vena cava

Paul Hatcher, E. E. Anderson, D. F. Paulson, C. C. Carson, J. E. Robertson

Research output: Contribution to journalArticle

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Abstract

A total of 44 patients with renal cell carcinoma and vena caval tumor thrombus underwent surgical resection. Of these patients 27 had primary tumor confined within Gerota's fascia, negative lymph nodes and no distant metastases (stage T3cN0M0). Patients who underwent extraction of a mobile tumor thrombus from the vena cava had a 69% 5-year survival rate (median 9.9 years) but patients with tumor thrombus directly invading the vena cava had a 26% 5-year survival rate (median 1.2 years), which improved to 57% (median 5.3 years) if the involved vena caval side wall was resected successfully. Of these patients 17 had renal cell carcinoma with vena caval thrombus as well as extrafascial extension, regional lymphadenopathy or distant metastases, and the 5-year survival rate was less than 18% in all groups (median survival less than 0.9 years). Prognosis was determined by the pathological stage of the renal cell carcinoma and by the presence or absence of vena caval side wall invasion but not by the level of tumor thrombus extension. Patients with incomplete resection of localized renal cell carcinoma with tumor thrombus do not survive any longer than those with extensive cancer, positive lymph nodes or distant metastases. However, when partial venacavectomy establishes negative surgical margins then survival markedly improves.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalJournal of Urology
Volume145
Issue number1
StatePublished - Jan 1 1991

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Venae Cavae
Renal Cell Carcinoma
Thrombosis
Neoplasms
Survival Rate
Neoplasm Metastasis
Lymph Nodes
Survival
Fascia

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Hatcher, P., Anderson, E. E., Paulson, D. F., Carson, C. C., & Robertson, J. E. (1991). Surgical management and prognosis of renal cell carcinoma invading the vena cava. Journal of Urology, 145(1), 20-23.

Surgical management and prognosis of renal cell carcinoma invading the vena cava. / Hatcher, Paul; Anderson, E. E.; Paulson, D. F.; Carson, C. C.; Robertson, J. E.

In: Journal of Urology, Vol. 145, No. 1, 01.01.1991, p. 20-23.

Research output: Contribution to journalArticle

Hatcher, P, Anderson, EE, Paulson, DF, Carson, CC & Robertson, JE 1991, 'Surgical management and prognosis of renal cell carcinoma invading the vena cava', Journal of Urology, vol. 145, no. 1, pp. 20-23.
Hatcher P, Anderson EE, Paulson DF, Carson CC, Robertson JE. Surgical management and prognosis of renal cell carcinoma invading the vena cava. Journal of Urology. 1991 Jan 1;145(1):20-23.
Hatcher, Paul ; Anderson, E. E. ; Paulson, D. F. ; Carson, C. C. ; Robertson, J. E. / Surgical management and prognosis of renal cell carcinoma invading the vena cava. In: Journal of Urology. 1991 ; Vol. 145, No. 1. pp. 20-23.
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