Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance

Wei Zhou, Michael Goodman, Robert H. Lyles, So Dug Lim, Tanisha Y. Williams, Kyle E. Rusthoven, Jack S. Mandel, Mahul Amin, John A. Petros

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND. Identification of prostate cancer patients at risk for postoperative disease recurrence is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors. METHODS. Using "counting alleles," a novel experimental method, we determined allelic status of chromosome 8p in 107 prostatectomy specimens. Statistical analyses examined the association between pathologic predictors (Gleason score, stage, surgical margin, etc.) and cancer recurrence in patients with and without 8p allelic imbalance (8p AI). RESULTS. 8p AI cancers were more likely to recur in the presence of a positive surgical margin, whereas recurrence of 8p retaining tumors was associated with the Gleason score, but not with the surgical margin. CONCLUSIONS. Our findings suggest that chromosome 8p allelic status affects the predictive value of "traditional" markers of prostate cancer recurrence. If confirmed by larger studies, these results may have important clinical implications.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalProstate
Volume61
Issue number1
DOIs
StatePublished - Sep 15 2004
Externally publishedYes

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Allelic Imbalance
Neoplasm Grading
Prostatic Neoplasms
Chromosomes
Recurrence
Neoplasms
Prostatectomy
Alleles
Margins of Excision

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

Cite this

Zhou, W., Goodman, M., Lyles, R. H., Lim, S. D., Williams, T. Y., Rusthoven, K. E., ... Petros, J. A. (2004). Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance. Prostate, 61(1), 81-91. https://doi.org/10.1002/pros.20086

Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance. / Zhou, Wei; Goodman, Michael; Lyles, Robert H.; Lim, So Dug; Williams, Tanisha Y.; Rusthoven, Kyle E.; Mandel, Jack S.; Amin, Mahul; Petros, John A.

In: Prostate, Vol. 61, No. 1, 15.09.2004, p. 81-91.

Research output: Contribution to journalArticle

Zhou, W, Goodman, M, Lyles, RH, Lim, SD, Williams, TY, Rusthoven, KE, Mandel, JS, Amin, M & Petros, JA 2004, 'Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance', Prostate, vol. 61, no. 1, pp. 81-91. https://doi.org/10.1002/pros.20086
Zhou, Wei ; Goodman, Michael ; Lyles, Robert H. ; Lim, So Dug ; Williams, Tanisha Y. ; Rusthoven, Kyle E. ; Mandel, Jack S. ; Amin, Mahul ; Petros, John A. / Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance. In: Prostate. 2004 ; Vol. 61, No. 1. pp. 81-91.
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T1 - Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance

AU - Zhou, Wei

AU - Goodman, Michael

AU - Lyles, Robert H.

AU - Lim, So Dug

AU - Williams, Tanisha Y.

AU - Rusthoven, Kyle E.

AU - Mandel, Jack S.

AU - Amin, Mahul

AU - Petros, John A.

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N2 - BACKGROUND. Identification of prostate cancer patients at risk for postoperative disease recurrence is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors. METHODS. Using "counting alleles," a novel experimental method, we determined allelic status of chromosome 8p in 107 prostatectomy specimens. Statistical analyses examined the association between pathologic predictors (Gleason score, stage, surgical margin, etc.) and cancer recurrence in patients with and without 8p allelic imbalance (8p AI). RESULTS. 8p AI cancers were more likely to recur in the presence of a positive surgical margin, whereas recurrence of 8p retaining tumors was associated with the Gleason score, but not with the surgical margin. CONCLUSIONS. Our findings suggest that chromosome 8p allelic status affects the predictive value of "traditional" markers of prostate cancer recurrence. If confirmed by larger studies, these results may have important clinical implications.

AB - BACKGROUND. Identification of prostate cancer patients at risk for postoperative disease recurrence is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors. METHODS. Using "counting alleles," a novel experimental method, we determined allelic status of chromosome 8p in 107 prostatectomy specimens. Statistical analyses examined the association between pathologic predictors (Gleason score, stage, surgical margin, etc.) and cancer recurrence in patients with and without 8p allelic imbalance (8p AI). RESULTS. 8p AI cancers were more likely to recur in the presence of a positive surgical margin, whereas recurrence of 8p retaining tumors was associated with the Gleason score, but not with the surgical margin. CONCLUSIONS. Our findings suggest that chromosome 8p allelic status affects the predictive value of "traditional" markers of prostate cancer recurrence. If confirmed by larger studies, these results may have important clinical implications.

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