Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients

Craig W. Hendrix, Janet M.J. Hammond, Sandra M. Swoboda, William G. Merz, Susan M. Harrington, Trish M. Perl, James D. Dick, Debaroti Borschel, Paul W. Halczenko, Robert K. Pelz, Laura E. Rocco, James E. Conway, Roy G. Brower, Pamela A. Lipsett

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: To determine the optimal site and frequency for vancomycin-resistant enterococci (VRE) surveillance to minimize the number of days of VRE colonization before identification and subsequent isolation. Summary Background Data: The increasing prevalence of VRE and the limited therapeutic options for its treatment demand early identification of colonization to prevent transmission. Methods: The authors conducted a 3-month prospective observational study in medical and surgical intensive care unit: (ICU) patients with a stay of 3 days or more. Oropharyngeal and rectal swabs, tracheal and gastric aspirates, and urine specimens were cultured for VRE oh admission to the ICU and twice weekly until discharge. Results: Of 117 evaluable patients, 23 (20%) were colonized by VRE. Twelve patients (10%) had VRE infection. Of nine patients who developed infections after ICU admission, eight were colonized before infection. The rectum was the first site of colonization in 92% of patients, and positive rectal cultures preceded 89% of infections acquired in the ICU. This was supported by strain delineations using pulsed-field gel electrophoresis. Twice-weekly rectal surveillance alone identified 93% of the maximal estimated VRE-related patient-days; weekly or admission-only surveillance was less effective. As a test for future VRE infection, rectal surveillance culture twice weekly had a negative predictive value of 99%, a positive predictive value of 44%, and a relative risk for infection of 34. Conclusions: Twice-weekly rectal VRE surveillance of critically ill patients is an effective strategy for early identification of colonized patients at increased risk for VRE transmission, infection, and death.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalAnnals of surgery
Volume233
Issue number2
DOIs
StatePublished - Feb 8 2001
Externally publishedYes

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Vancomycin
Critical Illness
Infection
Intensive Care Units
Vancomycin-Resistant Enterococci
Infectious Disease Transmission
Pulsed Field Gel Electrophoresis
Critical Care
Rectum
Observational Studies
Stomach
Urine
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Hendrix, C. W., Hammond, J. M. J., Swoboda, S. M., Merz, W. G., Harrington, S. M., Perl, T. M., ... Lipsett, P. A. (2001). Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients. Annals of surgery, 233(2), 259-265. https://doi.org/10.1097/00000658-200102000-00016

Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients. / Hendrix, Craig W.; Hammond, Janet M.J.; Swoboda, Sandra M.; Merz, William G.; Harrington, Susan M.; Perl, Trish M.; Dick, James D.; Borschel, Debaroti; Halczenko, Paul W.; Pelz, Robert K.; Rocco, Laura E.; Conway, James E.; Brower, Roy G.; Lipsett, Pamela A.

In: Annals of surgery, Vol. 233, No. 2, 08.02.2001, p. 259-265.

Research output: Contribution to journalArticle

Hendrix, CW, Hammond, JMJ, Swoboda, SM, Merz, WG, Harrington, SM, Perl, TM, Dick, JD, Borschel, D, Halczenko, PW, Pelz, RK, Rocco, LE, Conway, JE, Brower, RG & Lipsett, PA 2001, 'Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients', Annals of surgery, vol. 233, no. 2, pp. 259-265. https://doi.org/10.1097/00000658-200102000-00016
Hendrix, Craig W. ; Hammond, Janet M.J. ; Swoboda, Sandra M. ; Merz, William G. ; Harrington, Susan M. ; Perl, Trish M. ; Dick, James D. ; Borschel, Debaroti ; Halczenko, Paul W. ; Pelz, Robert K. ; Rocco, Laura E. ; Conway, James E. ; Brower, Roy G. ; Lipsett, Pamela A. / Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients. In: Annals of surgery. 2001 ; Vol. 233, No. 2. pp. 259-265.
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abstract = "Objective: To determine the optimal site and frequency for vancomycin-resistant enterococci (VRE) surveillance to minimize the number of days of VRE colonization before identification and subsequent isolation. Summary Background Data: The increasing prevalence of VRE and the limited therapeutic options for its treatment demand early identification of colonization to prevent transmission. Methods: The authors conducted a 3-month prospective observational study in medical and surgical intensive care unit: (ICU) patients with a stay of 3 days or more. Oropharyngeal and rectal swabs, tracheal and gastric aspirates, and urine specimens were cultured for VRE oh admission to the ICU and twice weekly until discharge. Results: Of 117 evaluable patients, 23 (20{\%}) were colonized by VRE. Twelve patients (10{\%}) had VRE infection. Of nine patients who developed infections after ICU admission, eight were colonized before infection. The rectum was the first site of colonization in 92{\%} of patients, and positive rectal cultures preceded 89{\%} of infections acquired in the ICU. This was supported by strain delineations using pulsed-field gel electrophoresis. Twice-weekly rectal surveillance alone identified 93{\%} of the maximal estimated VRE-related patient-days; weekly or admission-only surveillance was less effective. As a test for future VRE infection, rectal surveillance culture twice weekly had a negative predictive value of 99{\%}, a positive predictive value of 44{\%}, and a relative risk for infection of 34. Conclusions: Twice-weekly rectal VRE surveillance of critically ill patients is an effective strategy for early identification of colonized patients at increased risk for VRE transmission, infection, and death.",
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AU - Hendrix, Craig W.

AU - Hammond, Janet M.J.

AU - Swoboda, Sandra M.

AU - Merz, William G.

AU - Harrington, Susan M.

AU - Perl, Trish M.

AU - Dick, James D.

AU - Borschel, Debaroti

AU - Halczenko, Paul W.

AU - Pelz, Robert K.

AU - Rocco, Laura E.

AU - Conway, James E.

AU - Brower, Roy G.

AU - Lipsett, Pamela A.

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N2 - Objective: To determine the optimal site and frequency for vancomycin-resistant enterococci (VRE) surveillance to minimize the number of days of VRE colonization before identification and subsequent isolation. Summary Background Data: The increasing prevalence of VRE and the limited therapeutic options for its treatment demand early identification of colonization to prevent transmission. Methods: The authors conducted a 3-month prospective observational study in medical and surgical intensive care unit: (ICU) patients with a stay of 3 days or more. Oropharyngeal and rectal swabs, tracheal and gastric aspirates, and urine specimens were cultured for VRE oh admission to the ICU and twice weekly until discharge. Results: Of 117 evaluable patients, 23 (20%) were colonized by VRE. Twelve patients (10%) had VRE infection. Of nine patients who developed infections after ICU admission, eight were colonized before infection. The rectum was the first site of colonization in 92% of patients, and positive rectal cultures preceded 89% of infections acquired in the ICU. This was supported by strain delineations using pulsed-field gel electrophoresis. Twice-weekly rectal surveillance alone identified 93% of the maximal estimated VRE-related patient-days; weekly or admission-only surveillance was less effective. As a test for future VRE infection, rectal surveillance culture twice weekly had a negative predictive value of 99%, a positive predictive value of 44%, and a relative risk for infection of 34. Conclusions: Twice-weekly rectal VRE surveillance of critically ill patients is an effective strategy for early identification of colonized patients at increased risk for VRE transmission, infection, and death.

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