Survivors of childhood cancer in the United States

Prevalence and burden of morbidity

Siobhan M. Phillips, Lynne S. Padgett, Wendy M. Leisenring, Kayla K. Stratton, Ken Bishop, Kevin R. Krull, Catherine M. Alfano, Todd M. Gibson, Janet S. De Moor, Danielle Blanch Hartigan, Gregory Armstrong, Leslie L. Robison, Julia H. Rowland, Kevin C. Oeffinger, Angela B. Mariotto

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Background: No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this population reflected by chronic conditions, neurocognitive dysfunction, compromised health-related quality of life, and health status (general health, mental health, functional impairment, functional limitations, pain, and fear/anxiety). Methods: Surveillance, Epidemiology, and End Results (SEER) Program data from 1975 to 2011 were used to update the prevalence of survivors of childhood cancers in the United States. Childhood Cancer Survivor Study data were used to obtain estimates of morbidity burden indicators, which were then extrapolated to SEER data to obtain population-level estimates. Results: There were an estimated 388,501 survivors of childhood cancer in the United States as of January 1, 2011, of whom 83.5% are ≥5 years after diagnosis. The prevalence of any chronic condition among ≥5-year survivors ranged from66%(ages 5-19) to 88% (ages 40-49). Estimates for specific morbidities ranged from 12% (pain) to 35% (neurocognitive dysfunction). Generally, morbidities increased by age. However, mental health and anxiety remained fairly stable, and neurocognitive dysfunction exhibited initial decline and then remained stable by time since diagnosis. Conclusions: The estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years after diagnosis. Impact: Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority. Cancer Epidemiol Biomarkers Prev; 24(4); 653-63.

Original languageEnglish (US)
Pages (from-to)653-663
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Survivors
Morbidity
Neoplasms
Population
Mental Health
Anxiety
SEER Program
Pain
Tumor Biomarkers
Health Status
Fear
Epidemiology
Rehabilitation
Quality of Life
Health

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Phillips, S. M., Padgett, L. S., Leisenring, W. M., Stratton, K. K., Bishop, K., Krull, K. R., ... Mariotto, A. B. (2015). Survivors of childhood cancer in the United States: Prevalence and burden of morbidity. Cancer Epidemiology Biomarkers and Prevention, 24(4), 653-663. https://doi.org/10.1158/1055-9965.EPI-14-1418

Survivors of childhood cancer in the United States : Prevalence and burden of morbidity. / Phillips, Siobhan M.; Padgett, Lynne S.; Leisenring, Wendy M.; Stratton, Kayla K.; Bishop, Ken; Krull, Kevin R.; Alfano, Catherine M.; Gibson, Todd M.; De Moor, Janet S.; Hartigan, Danielle Blanch; Armstrong, Gregory; Robison, Leslie L.; Rowland, Julia H.; Oeffinger, Kevin C.; Mariotto, Angela B.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 4, 01.04.2015, p. 653-663.

Research output: Contribution to journalArticle

Phillips, SM, Padgett, LS, Leisenring, WM, Stratton, KK, Bishop, K, Krull, KR, Alfano, CM, Gibson, TM, De Moor, JS, Hartigan, DB, Armstrong, G, Robison, LL, Rowland, JH, Oeffinger, KC & Mariotto, AB 2015, 'Survivors of childhood cancer in the United States: Prevalence and burden of morbidity', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 4, pp. 653-663. https://doi.org/10.1158/1055-9965.EPI-14-1418
Phillips, Siobhan M. ; Padgett, Lynne S. ; Leisenring, Wendy M. ; Stratton, Kayla K. ; Bishop, Ken ; Krull, Kevin R. ; Alfano, Catherine M. ; Gibson, Todd M. ; De Moor, Janet S. ; Hartigan, Danielle Blanch ; Armstrong, Gregory ; Robison, Leslie L. ; Rowland, Julia H. ; Oeffinger, Kevin C. ; Mariotto, Angela B. / Survivors of childhood cancer in the United States : Prevalence and burden of morbidity. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 4. pp. 653-663.
@article{12d918397985413aa85d08bfcd4e0900,
title = "Survivors of childhood cancer in the United States: Prevalence and burden of morbidity",
abstract = "Background: No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this population reflected by chronic conditions, neurocognitive dysfunction, compromised health-related quality of life, and health status (general health, mental health, functional impairment, functional limitations, pain, and fear/anxiety). Methods: Surveillance, Epidemiology, and End Results (SEER) Program data from 1975 to 2011 were used to update the prevalence of survivors of childhood cancers in the United States. Childhood Cancer Survivor Study data were used to obtain estimates of morbidity burden indicators, which were then extrapolated to SEER data to obtain population-level estimates. Results: There were an estimated 388,501 survivors of childhood cancer in the United States as of January 1, 2011, of whom 83.5{\%} are ≥5 years after diagnosis. The prevalence of any chronic condition among ≥5-year survivors ranged from66{\%}(ages 5-19) to 88{\%} (ages 40-49). Estimates for specific morbidities ranged from 12{\%} (pain) to 35{\%} (neurocognitive dysfunction). Generally, morbidities increased by age. However, mental health and anxiety remained fairly stable, and neurocognitive dysfunction exhibited initial decline and then remained stable by time since diagnosis. Conclusions: The estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years after diagnosis. Impact: Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority. Cancer Epidemiol Biomarkers Prev; 24(4); 653-63.",
author = "Phillips, {Siobhan M.} and Padgett, {Lynne S.} and Leisenring, {Wendy M.} and Stratton, {Kayla K.} and Ken Bishop and Krull, {Kevin R.} and Alfano, {Catherine M.} and Gibson, {Todd M.} and {De Moor}, {Janet S.} and Hartigan, {Danielle Blanch} and Gregory Armstrong and Robison, {Leslie L.} and Rowland, {Julia H.} and Oeffinger, {Kevin C.} and Mariotto, {Angela B.}",
year = "2015",
month = "4",
day = "1",
doi = "10.1158/1055-9965.EPI-14-1418",
language = "English (US)",
volume = "24",
pages = "653--663",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - Survivors of childhood cancer in the United States

T2 - Prevalence and burden of morbidity

AU - Phillips, Siobhan M.

AU - Padgett, Lynne S.

AU - Leisenring, Wendy M.

AU - Stratton, Kayla K.

AU - Bishop, Ken

AU - Krull, Kevin R.

AU - Alfano, Catherine M.

AU - Gibson, Todd M.

AU - De Moor, Janet S.

AU - Hartigan, Danielle Blanch

AU - Armstrong, Gregory

AU - Robison, Leslie L.

AU - Rowland, Julia H.

AU - Oeffinger, Kevin C.

AU - Mariotto, Angela B.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this population reflected by chronic conditions, neurocognitive dysfunction, compromised health-related quality of life, and health status (general health, mental health, functional impairment, functional limitations, pain, and fear/anxiety). Methods: Surveillance, Epidemiology, and End Results (SEER) Program data from 1975 to 2011 were used to update the prevalence of survivors of childhood cancers in the United States. Childhood Cancer Survivor Study data were used to obtain estimates of morbidity burden indicators, which were then extrapolated to SEER data to obtain population-level estimates. Results: There were an estimated 388,501 survivors of childhood cancer in the United States as of January 1, 2011, of whom 83.5% are ≥5 years after diagnosis. The prevalence of any chronic condition among ≥5-year survivors ranged from66%(ages 5-19) to 88% (ages 40-49). Estimates for specific morbidities ranged from 12% (pain) to 35% (neurocognitive dysfunction). Generally, morbidities increased by age. However, mental health and anxiety remained fairly stable, and neurocognitive dysfunction exhibited initial decline and then remained stable by time since diagnosis. Conclusions: The estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years after diagnosis. Impact: Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority. Cancer Epidemiol Biomarkers Prev; 24(4); 653-63.

AB - Background: No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this population reflected by chronic conditions, neurocognitive dysfunction, compromised health-related quality of life, and health status (general health, mental health, functional impairment, functional limitations, pain, and fear/anxiety). Methods: Surveillance, Epidemiology, and End Results (SEER) Program data from 1975 to 2011 were used to update the prevalence of survivors of childhood cancers in the United States. Childhood Cancer Survivor Study data were used to obtain estimates of morbidity burden indicators, which were then extrapolated to SEER data to obtain population-level estimates. Results: There were an estimated 388,501 survivors of childhood cancer in the United States as of January 1, 2011, of whom 83.5% are ≥5 years after diagnosis. The prevalence of any chronic condition among ≥5-year survivors ranged from66%(ages 5-19) to 88% (ages 40-49). Estimates for specific morbidities ranged from 12% (pain) to 35% (neurocognitive dysfunction). Generally, morbidities increased by age. However, mental health and anxiety remained fairly stable, and neurocognitive dysfunction exhibited initial decline and then remained stable by time since diagnosis. Conclusions: The estimated prevalence of survivors of childhood cancer is increasing, as is the estimated prevalence of morbidity in those ≥5 years after diagnosis. Impact: Efforts to understand how to effectively decrease morbidity burden and incorporate effective care coordination and rehabilitation models to optimize longevity and well-being in this population should be a priority. Cancer Epidemiol Biomarkers Prev; 24(4); 653-63.

UR - http://www.scopus.com/inward/record.url?scp=84927943291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927943291&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-14-1418

DO - 10.1158/1055-9965.EPI-14-1418

M3 - Article

VL - 24

SP - 653

EP - 663

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 4

ER -