SWR mice are resistant to collagen‐induced arthritis but produce potentially arthritogenic antibodies

Robert A. Reife, Nikolous Loutis, William C. Watson, Karen Hasty, John Stuart

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

SWR mice are resistant to collagen‐induced arthritis but produce antibodies to type II collagen. To determine if these antibodies have arthritogenic potential, serum from collagen‐immunized mice was concentrated and passively transferred to DBA/1 mice. The recipients developed severe arthritis within 72 hours. To evaluate the role of complement, SWR mice were bred with congenic inbred B10.D2/oSn (complement deficient) and B10.D2/nSn (complement normal) mice. Collagen‐immunized (SWR × B10.D2/nSn)F1 mice had high levels of C5 and were susceptible to arthritis, while (SWR × B10.D2/oSn)F1 mice were deficient in C5 and were resistant to arthritis.

Original languageEnglish (US)
Pages (from-to)776-781
Number of pages6
JournalArthritis & Rheumatism
Volume34
Issue number6
DOIs
StatePublished - Jan 1 1991

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Arthritis
Antibodies
Inbred DBA Mouse
Collagen Type II
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

SWR mice are resistant to collagen‐induced arthritis but produce potentially arthritogenic antibodies. / Reife, Robert A.; Loutis, Nikolous; Watson, William C.; Hasty, Karen; Stuart, John.

In: Arthritis & Rheumatism, Vol. 34, No. 6, 01.01.1991, p. 776-781.

Research output: Contribution to journalArticle

Reife, Robert A. ; Loutis, Nikolous ; Watson, William C. ; Hasty, Karen ; Stuart, John. / SWR mice are resistant to collagen‐induced arthritis but produce potentially arthritogenic antibodies. In: Arthritis & Rheumatism. 1991 ; Vol. 34, No. 6. pp. 776-781.
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