Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent

Mohamed Y. Elsaid, Kara G. Gill, Ankush Gosain, Peter F. Nichol, Charles M. Leys, Darya Buehler, Catherine P. Leith, Neha J. Patel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. Observation: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. Conclusions: This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.

Original languageEnglish (US)
Pages (from-to)e399-e402
JournalJournal of Pediatric Hematology/Oncology
Volume39
Issue number7
DOIs
StatePublished - Jan 1 2017

Fingerprint

Hodgkin Disease
Renal Cell Carcinoma
Neoplasms
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
Cytogenetic Analysis
Hematologic Neoplasms
Lymph Node Excision
Nephrectomy
Cytogenetics
Tomography
Observation
Kidney
Drug Therapy
Mutation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent. / Elsaid, Mohamed Y.; Gill, Kara G.; Gosain, Ankush; Nichol, Peter F.; Leys, Charles M.; Buehler, Darya; Leith, Catherine P.; Patel, Neha J.

In: Journal of Pediatric Hematology/Oncology, Vol. 39, No. 7, 01.01.2017, p. e399-e402.

Research output: Contribution to journalArticle

Elsaid, MY, Gill, KG, Gosain, A, Nichol, PF, Leys, CM, Buehler, D, Leith, CP & Patel, NJ 2017, 'Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent', Journal of Pediatric Hematology/Oncology, vol. 39, no. 7, pp. e399-e402. https://doi.org/10.1097/MPH.0000000000000769
Elsaid, Mohamed Y. ; Gill, Kara G. ; Gosain, Ankush ; Nichol, Peter F. ; Leys, Charles M. ; Buehler, Darya ; Leith, Catherine P. ; Patel, Neha J. / Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent. In: Journal of Pediatric Hematology/Oncology. 2017 ; Vol. 39, No. 7. pp. e399-e402.
@article{a3b8c31f510e4543a825386106ed37e5,
title = "Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent",
abstract = "Background: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. Observation: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. Conclusions: This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.",
author = "Elsaid, {Mohamed Y.} and Gill, {Kara G.} and Ankush Gosain and Nichol, {Peter F.} and Leys, {Charles M.} and Darya Buehler and Leith, {Catherine P.} and Patel, {Neha J.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/MPH.0000000000000769",
language = "English (US)",
volume = "39",
pages = "e399--e402",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent

AU - Elsaid, Mohamed Y.

AU - Gill, Kara G.

AU - Gosain, Ankush

AU - Nichol, Peter F.

AU - Leys, Charles M.

AU - Buehler, Darya

AU - Leith, Catherine P.

AU - Patel, Neha J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. Observation: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. Conclusions: This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.

AB - Background: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. Observation: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. Conclusions: This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.

UR - http://www.scopus.com/inward/record.url?scp=85009732665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009732665&partnerID=8YFLogxK

U2 - 10.1097/MPH.0000000000000769

DO - 10.1097/MPH.0000000000000769

M3 - Article

VL - 39

SP - e399-e402

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 7

ER -