Syntheses of 4-(1-alkynyl)-2(5H)-furanones and coumarins via the palladium catalyzed cross-coupling reactions of potassium alkynyltrifluoroborates

George Kabalka, Gang Dong, Bollu Venkataiah

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An efficient synthesis of 4-(1-alkynyl)-2(5H)-furanones has been developed utilizing a palladium catalyzed coupling reaction of β-tetronic acid bromide with potassium alkynyltrifluoroborates in the absence of base. 4-Alkynylcoumarins were also synthesized using this method. The reactions are straightforward and the yields are excellent.

Original languageEnglish (US)
Pages (from-to)5139-5141
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number26
DOIs
StatePublished - Jun 21 2004
Externally publishedYes

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Coumarins
Cross Reactions
Palladium
Bromides
Potassium
potassium bromide
tetronic acid
butenolide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Syntheses of 4-(1-alkynyl)-2(5H)-furanones and coumarins via the palladium catalyzed cross-coupling reactions of potassium alkynyltrifluoroborates. / Kabalka, George; Dong, Gang; Venkataiah, Bollu.

In: Tetrahedron Letters, Vol. 45, No. 26, 21.06.2004, p. 5139-5141.

Research output: Contribution to journalArticle

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